Showing metabocard for Fructose 6-phosphate (BMDB0000124)

General function:

Carbohydrate transport and metabolism

Specific function:

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

Gene Name:

TALDO1

Uniprot ID:

Q2TBL6

Molecular weight:

37685.0

General function:

Carbohydrate transport and metabolism

Specific function:

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

Gene Name:

TALDO1

Uniprot ID:

Q58DR3

Molecular weight:

23712.0

General function:

Carbohydrate transport and metabolism

Specific function:

Synthesis and degradation of fructose 2,6-bisphosphate.

Gene Name:

PFKFB1

Uniprot ID:

P49872

Molecular weight:

54657.0

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations and probably participates in glycogen synthesis from carbohydrate precursors, such as lactate.

Gene Name:

FBP2

Uniprot ID:

Q2KJJ9

Molecular weight:

36767.0

General function:

Carbohydrate transport and metabolism

Specific function:

Synthesis and degradation of fructose 2,6-bisphosphate.

Gene Name:

PFKFB3

Uniprot ID:

Q28901

Molecular weight:

53584.0

General function:

Carbohydrate transport and metabolism

Specific function:

Synthesis and degradation of fructose 2,6-bisphosphate.

Gene Name:

PFKFB2

Uniprot ID:

P26285

Molecular weight:

60811.0

General function:

Carbohydrate transport and metabolism

Specific function:

Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.

Gene Name:

FBP1

Uniprot ID:

Q3SZB7

Molecular weight:

36728.0

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity).

Gene Name:

PFKL

Uniprot ID:

A1A4J1

Molecular weight:

85292.0

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Gene Name:

PFKM

Uniprot ID:

Q0IIG5

Molecular weight:

85294.0

General function:

Energy production and conversion

Specific function:

Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.

Gene Name:

TKT

Uniprot ID:

Q6B855

Molecular weight:

67906.0

Reactions

General function:

Cell wall/membrane/envelope biogenesis

Specific function:

Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins (By similarity).

Gene Name:

GFPT2

Uniprot ID:

Q08DQ2

Molecular weight:

77081.0

Reactions

General function:

Involved in ATP binding

Specific function:

Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan. When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (By similarity).

Gene Name:

HK1

Uniprot ID:

P27595

Molecular weight:

103064.0

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.

Gene Name:

MPI

Uniprot ID:

Q3SZI0

Molecular weight:

46369.0

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate (By similarity). Acts as a negative regulator of glycolysis by lowering intracellular levels of fructose-2,6-bisphosphate in a p53/TP53-dependent manner, resulting in the pentose phosphate pathway (PPP) activation and NADPH production. Contributes to the generation of reduced glutathione to cause a decrease in intracellular reactive oxygen species (ROS) content, correlating with its ability to protect cells from oxidative or metabolic stress-induced cell death. Plays a role in promoting protection against cell death during hypoxia by decreasing mitochondria ROS levels in a HK2-dependent manner through a mechanism that is independent of its fructose-bisphosphatase activity. In response to cardiac damage stress, mediates p53-induced inhibition of myocyte mitophagy through ROS levels reduction and the subsequent inactivation of BNIP3. Reduced mitophagy results in an enhanced apoptotic myocyte cell death, and exacerbates cardiac damage. Plays a role in adult intestinal regeneration; contributes to the growth, proliferation and survival of intestinal crypts following tissue ablation. Plays a neuroprotective role against ischemic brain damage by enhancing PPP flux and preserving mitochondria functions. Protects glioma cells from hypoxia- and ROS-induced cell death by inhibiting glycolysis and activating mitochondrial energy metabolism and oxygen consumption in a TKTL1-dependent and p53/TP53-independent manner. Plays a role in cancer cell survival by promoting DNA repair through activating PPP flux in a CDK5-ATM-dependent signaling pathway during hypoxia and/or genome stress-induced DNA damage responses. Involved in intestinal tumor progression.

Gene Name:

TIGAR

Uniprot ID:

Q1JQA7

Molecular weight:

29467.0

General function:

Carbohydrate transport and metabolism

Specific function:

In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis (By similarity). Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion (By similarity).

Gene Name:

GPI

Uniprot ID:

Q3ZBD7

Molecular weight:

62855.0

Reactions

General function:

Not Available

Specific function:

Seems to trigger calcium oscillations in mammalian eggs. These oscillations serve as the essential trigger for egg activation and early development of the embryo (By similarity).

Gene Name:

GNPDA1

Uniprot ID:

A4FV08

Molecular weight:

32580.0

Reactions