Showing metabocard for L-Histidine (BMDB0000177)

General function:

Involved in histone binding

Specific function:

Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53 (By similarity). Repression of TP53 blocks cellular senescence (By similarity). Also methylates histone H2A and H4 'Arg-3' (H2AR3me and H4R3me, respectively). Acts as a regulator of DNA base excision during DNA repair by mediating the methylation of DNA polymerase beta (POLB), leading to the stimulation of its polymerase activity by enhancing DNA binding and processivity. Methylates HMGA1. Regulates alternative splicing events. Acts as a transcriptional coactivator of a number of steroid hormone receptors including ESR1, ESR2, PGR and NR3C1. Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator. Methylates GPS2, protecting GPS2 from ubiquitination and degradation. Methylates SIRT7, inhibiting SIRT7 histone deacetylase activity and promoting mitochondria biogenesis (By similarity).

Gene Name:

PRMT6

Uniprot ID:

Q5E9L5

Molecular weight:

41868.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the biosynthesis of histamine from histidine.

Gene Name:

HDC

Uniprot ID:

Q5EA83

Molecular weight:

73912.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Hydrolyzes a variety of dipeptides including L-carnosine but has a strong preference for Cys-Gly. Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverse proteolysis.

Gene Name:

CNDP2

Uniprot ID:

Q3ZC84

Molecular weight:

52655.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

Hydrolase probably involved in steroid biosynthesis. May play a role in apoptosis. Has adenosine phosphoramidase activity (By similarity).

Gene Name:

HINT2

Uniprot ID:

Q8SQ21

Molecular weight:

17147.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

HAL

Uniprot ID:

A7YWP4

Molecular weight:

72291.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

Hydrolyzes phosphoramidate and acyl-adenylate substrates.

Gene Name:

HINT3

Uniprot ID:

Q2YDJ4

Molecular weight:

20470.0

General function:

Involved in serine-type peptidase activity

Specific function:

Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP). Promotes changes in mitochondria morphology regulated by phosphorylation of P-beta domain (By similarity).

Gene Name:

PARL

Uniprot ID:

Q2KHV4

Molecular weight:

42301.0

General function:

Nucleotide transport and metabolism

Specific function:

Hydrolyzes purine nucleotide phosphoramidates with a single phosphate group, including adenosine 5'monophosphoramidate (AMP-NH2), adenosine 5'monophosphomorpholidate (AMP-morpholidate) and guanosine 5'monophosphomorpholidate (GMP-morpholidate). Hydrolyzes lysyl-AMP (AMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) generated by lysine tRNA ligase, as well as Met-AMP, His-AMP and Asp-AMP, lysyl-GMP (GMP-N-epsilon-(N-alpha-acetyl lysine methyl ester)) and AMP-N-alanine methyl ester. Can also convert adenosine 5'-O-phosphorothioate and guanosine 5'-O-phosphorothioate to the corresponding nucleoside 5'-O-phosphates with concomitant release of hydrogen sulfide. In addition, functions as scaffolding protein that modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex and by the complex formed with MITF and CTNNB1. Modulates p53/TP53 levels and p53/TP53-mediated apoptosis. Modulates proteasomal degradation of target proteins by the SCF (SKP2-CUL1-F-box protein) E3 ubiquitin-protein ligase complex (By similarity).

Gene Name:

HINT1

Uniprot ID:

P62958

Molecular weight:

13779.0

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance.

Gene Name:

HARS1

Uniprot ID:

Q2KI84

Molecular weight:

57285.0

Reactions

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP).

Gene Name:

HARS2

Uniprot ID:

A5D7V9

Molecular weight:

56914.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium (By similarity).

Gene Name:

SLC38A5

Uniprot ID:

Q5E9S9

Molecular weight:

51958.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

Q866Q8

Molecular weight:

21625.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

SLC38A3

Uniprot ID:

Q3MHG9

Molecular weight:

40823.0

General function:

Involved in L-glutamine transmembrane transporter activity

Specific function:

Not Available

Gene Name:

SLC38A3

Uniprot ID:

B0LSH5

Molecular weight:

2581.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

SLC38A3

Uniprot ID:

Q5BIN7

Molecular weight:

55315.0

General function:

Nucleotide transport and metabolism

Specific function:

Not Available

Gene Name:

HINT1

Uniprot ID:

A1XEA3

Molecular weight:

6000.0

General function:

Not Available

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

A5PJL9

Molecular weight:

54461.0

Reactions