Showing metabocard for L-Aspartic acid (BMDB0000191)

General function:

Nucleotide transport and metabolism

Specific function:

One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.

Gene Name:

ASS1

Uniprot ID:

P14568

Molecular weight:

46417.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

Gene Name:

ADSS1

Uniprot ID:

A5PJR4

Molecular weight:

50134.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.

Gene Name:

ADSS2

Uniprot ID:

A7MBG0

Molecular weight:

50156.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter (By similarity).

Gene Name:

ASPA

Uniprot ID:

P46446

Molecular weight:

35738.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

ASNS

Uniprot ID:

Q1LZA3

Molecular weight:

64220.0

Reactions

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

Gene Name:

DARS1

Uniprot ID:

Q3SYZ4

Molecular weight:

57036.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.

Gene Name:

ASRGL1

Uniprot ID:

Q32LE5

Molecular weight:

32050.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Aminopeptidase with specificity towards an acidic amino acid at the N-terminus. Likely to play an important role in intracellular protein and peptide metabolism (By similarity).

Gene Name:

DNPEP

Uniprot ID:

Q2HJH1

Molecular weight:

51828.0

General function:

Amino acid transport and metabolism

Specific function:

Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity).

Gene Name:

GOT1

Uniprot ID:

P33097

Molecular weight:

46399.0

Reactions

General function:

Posttranslational modification, protein turnover, chaperones

Specific function:

Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins.

Gene Name:

ASPH

Uniprot ID:

Q28056

Molecular weight:

84999.0

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity).

Gene Name:

GOT2

Uniprot ID:

P12344

Molecular weight:

47514.0

Reactions

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Not Available

Gene Name:

DARS2

Uniprot ID:

A6QPU5

Molecular weight:

73688.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

GOT1L1

Uniprot ID:

Q2T9S8

Molecular weight:

45918.0

General function:

Amino acid transport and metabolism

Specific function:

Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II.

Gene Name:

ENPEP

Uniprot ID:

Q32LQ0

Molecular weight:

109801.0

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the production of GABA.

Gene Name:

GAD1

Uniprot ID:

Q0VCA1

Molecular weight:

66784.0

Reactions

General function:

Involved in binding

Specific function:

Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Maintains mitochondrial fusion and fission events, and the organization and morphology of cristae. Involved in the regulation of apoptosis.

Gene Name:

SLC25A11

Uniprot ID:

P22292

Molecular weight:

34172.0

General function:

Not Available

Specific function:

Not Available

Gene Name:

IL4I1

Uniprot ID:

F1N191

Molecular weight:

64479.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

CAD

Uniprot ID:

F1MVC0

Molecular weight:

243038.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

PAICS

Uniprot ID:

Q2HJ26

Molecular weight:

47122.0

Reactions