Showing metabocard for Pyruvic acid (BMDB0000243)

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

SDS

Uniprot ID:

Q0VCW4

Molecular weight:

34441.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the cleavage of N-acetylneuraminic acid (sialic acid) to form pyruvate and N-acetylmannosamine via a Schiff base intermediate. It prevents sialic acids from being recycled and returning to the cell surface. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway (By similarity).

Gene Name:

NPL

Uniprot ID:

Q29RY9

Molecular weight:

35166.0

Reactions

General function:

Inorganic ion transport and metabolism

Specific function:

Together with MRPL18, acts as a mitochondrial import factor for the cytosolic 5S rRNA. Only the nascent unfolded cytoplasmic form is able to bind to the 5S rRNA (By similarity). Formation of iron-sulfur complexes and cyanide detoxification. Binds molecular oxygen and sulfur.

Gene Name:

TST

Uniprot ID:

P00586

Molecular weight:

33296.0

Reactions

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

PKM

Uniprot ID:

B3IVN4

Molecular weight:

16527.0

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

PKM2

Uniprot ID:

Q3ZC87

Molecular weight:

61428.0

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

PKLR

Uniprot ID:

Q1JPG7

Molecular weight:

56870.0

General function:

Carbohydrate transport and metabolism

Specific function:

Not Available

Gene Name:

PKM

Uniprot ID:

A5D984

Molecular weight:

57949.0

Reactions

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

LDHAL6B

Uniprot ID:

Q3T056

Molecular weight:

41592.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

LDHB

Uniprot ID:

Q5E9B1

Molecular weight:

36724.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

LDHA

Uniprot ID:

P19858

Molecular weight:

36598.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

LDHB

Uniprot ID:

B0JYN3

Molecular weight:

36725.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

LDHC

Uniprot ID:

Q2KJG0

Molecular weight:

26074.0

General function:

Involved in ATP binding

Specific function:

Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate (By similarity).

Gene Name:

PC

Uniprot ID:

Q29RK2

Molecular weight:

129698.0

Reactions

General function:

Energy production and conversion

Specific function:

Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex.

Gene Name:

PDHX

Uniprot ID:

P22439

Molecular weight:

53886.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure (By similarity).

Gene Name:

AGXT2

Uniprot ID:

Q17QF0

Molecular weight:

57226.0

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration of target proteins: sulfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby regulating their function (By similarity).

Gene Name:

CTH

Uniprot ID:

Q58DW2

Molecular weight:

44406.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity).

Gene Name:

GPT

Uniprot ID:

A4IFH5

Molecular weight:

55275.0

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity).

Gene Name:

KYAT3

Uniprot ID:

Q0P5G4

Molecular weight:

51472.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

ALDH2

Uniprot ID:

P20000

Molecular weight:

56653.0

Reactions

General function:

Energy production and conversion

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

Gene Name:

PDHA1

Uniprot ID:

A7MB35

Molecular weight:

43388.0

Reactions

General function:

Energy production and conversion

Specific function:

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.

Gene Name:

PDHB

Uniprot ID:

P11966

Molecular weight:

39126.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

AGXT

Uniprot ID:

A7MBF1

Molecular weight:

45292.0

Reactions

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

ME1

Uniprot ID:

B8YB77

Molecular weight:

63372.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

DLD

Uniprot ID:

F1N206

Molecular weight:

54187.0

Reactions