Showing metabocard for L-Arginine (BMDB0000517)

General function:

Inorganic ion transport and metabolism

Specific function:

Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.

Gene Name:

NOS3

Uniprot ID:

P29473

Molecular weight:

133287.0

Reactions

General function:

Inorganic ion transport and metabolism

Specific function:

Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8.

Gene Name:

NOS2

Uniprot ID:

Q27995

Molecular weight:

131208.0

General function:

Involved in calcium ion binding

Specific function:

Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity).

Gene Name:

PLCG1

Uniprot ID:

P08487

Molecular weight:

148313.0

General function:

Posttranslational modification, protein turnover, chaperones

Specific function:

Specifically acts as a arginine mono-ADP-ribosylhydrolase by mediating the removal of mono-ADP-ribose attached to arginine residues on proteins.

Gene Name:

ADPRH

Uniprot ID:

Q32KR8

Molecular weight:

39152.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

ASL

Uniprot ID:

Q3SZJ0

Molecular weight:

52743.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.

Gene Name:

CPE

Uniprot ID:

P04836

Molecular weight:

53309.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

ARG1

Uniprot ID:

Q2KJ64

Molecular weight:

35009.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

CPB1

Uniprot ID:

P00732

Molecular weight:

47348.0

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Not Available

Gene Name:

RARS2

Uniprot ID:

Q0P5H7

Molecular weight:

65631.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity).

Gene Name:

GATM

Uniprot ID:

Q2HJ74

Molecular weight:

48357.0

Reactions

General function:

Involved in arginine binding

Specific function:

Not Available

Gene Name:

iNOS

Uniprot ID:

Q6ZXD5

Molecular weight:

12093.0

General function:

Amino acid transport and metabolism

Specific function:

May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to nitric oxid synthase (NOS). Arginine metabolism is a critical regulator of innate and adaptive immune responses. Seems to be involved in negative regulation of the survival capacity of activated T cells. May suppress inflammation-related signaling in asthmatic airway epithelium. May play a role in promoting prenatal immune suppression. Regulates RPS6KB1 signaling, which promotes endothelial cell senescence and inflammation and implicates NOS3/eNOS dysfunction. Can inhibit endothelial autophagy independently of its enzymatic activity implicating mTORC2 signaling. Involved in vascular smooth muscle cell senescence and apoptosis independently of its enzymatic activity.

Gene Name:

ARG2

Uniprot ID:

Q58DL1

Molecular weight:

38616.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

SLC7A1

Uniprot ID:

Q27IK9

Molecular weight:

24957.0

General function:

Not Available

Specific function:

Involved in renal water reabsorption. Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

Gene Name:

AVPR2

Uniprot ID:

C5HF06

Molecular weight:

40236.0

General function:

Involved in vasopressin receptor activity

Specific function:

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system.

Gene Name:

Not Available

Uniprot ID:

Q95L48

Molecular weight:

23433.0

General function:

Involved in vasopressin receptor activity

Specific function:

Receptor for arginine vasopressin (PubMed:7698346, PubMed:8257689). The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption (By similarity).

Gene Name:

AVPR2

Uniprot ID:

P48044

Molecular weight:

40236.0

General function:

Amino acid transport and metabolism

Specific function:

Not Available

Gene Name:

SLC7A3

Uniprot ID:

A0JNF2

Molecular weight:

67045.0

General function:

Not Available

Specific function:

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.

Gene Name:

RARS1

Uniprot ID:

A7YW98

Molecular weight:

75561.0

Reactions