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Record Information
Version1.0
Creation Date2016-09-30 22:44:21 UTC
Update Date2020-05-21 16:28:58 UTC
BMDB IDBMDB0001338
Secondary Accession Numbers
  • BMDB01338
Metabolite Identification
Common NamePalmityl-CoA
DescriptionPalmityl-CoA, also known as palmitoyl CoA or CoA, palmitoyl, belongs to the class of organic compounds known as long-chain fatty acyl coas. These are acyl CoAs where the group acylated to the coenzyme A moiety is a long aliphatic chain of 13 to 21 carbon atoms. Palmityl-CoA is possibly soluble (in water) and a strong basic compound (based on its pKa). Palmityl-CoA exists in all living species, ranging from bacteria to humans. Palmityl-CoA participates in a number of enzymatic reactions, within cattle. In particular, Palmityl-CoA and glycerol 3-phosphate can be converted into lpa(16:0/0:0); which is mediated by the enzyme glycerol-3-phosphate acyltransferase. In addition, Lpa(16:0/0:0) and palmityl-CoA can be converted into PA(16:0/16:0); which is catalyzed by the enzyme 1-acyl-sn-glycerol-3-phosphate acyltransferase. In cattle, palmityl-CoA is involved in a couple of metabolic pathways, which include de novo triacylglycerol biosynthesis TG(16:0/16:0/16:0) pathway and the glycerolipid metabolism pathway.
Structure
Thumb
Synonyms
ValueSource
coenzyme A, S-HexadecanoateChEBI
Palmitoyl coenzyme AChEBI
S-Palmitoylcoenzyme AChEBI
coenzyme A, S-Hexadecanoic acidGenerator
Hexadecanoyl-CoAChEBI
CoA, HexadecanoylMeSH
CoA, PalmitylMeSH
Hexadecanoyl CoAMeSH
coenzyme A, PalmitoylMeSH
Palmityl CoAMeSH
CoA, PalmitoylMeSH
Palmitoyl CoAMeSH
Hexadecanoyl-coenzyme AHMDB
Palmityl coenzyme AHMDB
Palmityl-CoAHMDB
Palmityl-coenzyme AHMDB
S-Palmityl coenzyme AHMDB
S-Palmityl-CoAHMDB
S-Palmityl-coenzyme AHMDB
Chemical FormulaC37H66N7O17P3S
Average Molecular Weight1005.943
Monoisotopic Molecular Weight1005.344873947
IUPAC Name{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-2-({[({[(3R)-3-[(2-{[2-(hexadecanoylsulfanyl)ethyl]carbamoyl}ethyl)carbamoyl]-3-hydroxy-2,2-dimethylpropoxy](hydroxy)phosphoryl}oxy)(hydroxy)phosphoryl]oxy}methyl)-4-hydroxyoxolan-3-yl]oxy}phosphonic acid
Traditional Namepalmitoyl-coa
CAS Registry Number1763-10-6
SMILES
CCCCCCCCCCCCCCCC(=O)SCCNC(=O)CCNC(=O)[C@H](O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N
InChI Identifier
InChI=1S/C37H66N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h24-26,30-32,36,47-48H,4-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/t26-,30-,31-,32+,36-/m1/s1
InChI KeyMNBKLUUYKPBKDU-BBECNAHFSA-N
Chemical Taxonomy
Description belongs to the class of organic compounds known as hexoses. These are monosaccharides in which the sugar unit is a is a six-carbon containing moeity.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassCarbohydrates and carbohydrate conjugates
Direct ParentHexoses
Alternative Parents
Substituents
  • Hexose monosaccharide
  • Oxane
  • Secondary alcohol
  • Hemiacetal
  • Oxacycle
  • Organoheterocyclic compound
  • Polyol
  • Hydrocarbon derivative
  • Alcohol
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External Descriptors
Ontology
StatusExpected but not Quantified
Origin
  • Endogenous
  • Exogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Cell membrane
  • Cytoplasm
  • Membrane
  • Mitochondria
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP2.35ALOGPS
logP0.6ChemAxon
logS-2.8ALOGPS
pKa (Strongest Acidic)0.82ChemAxon
pKa (Strongest Basic)4.01ChemAxon
Physiological Charge-4ChemAxon
Hydrogen Acceptor Count17ChemAxon
Hydrogen Donor Count9ChemAxon
Polar Surface Area363.63 ŲChemAxon
Rotatable Bond Count34ChemAxon
Refractivity236.65 m³·mol⁻¹ChemAxon
Polarizability102.2 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000i-2709000101-7863d2df84c4c4e06bd2View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-000i-1829200000-77fb81a8f15c5d2b616cView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-000i-1914000000-016e1dd6b88c119f09b8View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0far-8971333504-cdf5697f5a74af8e63d1View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-001r-2910301001-24e89da24748049880afView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-056r-7900100000-2cd78f62ff0a7c2cb5b8View in MoNA
Biological Properties
Cellular Locations
  • Cell membrane
  • Cytoplasm
  • Membrane
  • Mitochondria
Biospecimen Locations
  • Brain
  • Erythrocyte
  • Fibroblasts
  • Heart
  • Kidney
  • Liver
  • Lung
  • Neuron
  • Pancreas
  • Placenta
  • Skeletal Muscle
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BrainExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
details
ErythrocyteExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
details
FibroblastsExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
details
HeartExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
details
KidneyExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
details
LiverExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
details
LungExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
details
NeuronExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
details
PancreasExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
details
PlacentaExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
details
Skeletal MuscleExpected but not QuantifiedNot QuantifiedNot SpecifiedNot SpecifiedNormal
  • Not Applicable
details
Abnormal Concentrations
Not Available
HMDB IDHMDB0001338
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB022562
KNApSAcK IDC00007462
Chemspider ID559149
KEGG Compound IDC00154
BioCyc IDPALMITYL-COA
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound644109
PDB IDNot Available
ChEBI ID15525
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

General function:
Coenzyme transport and metabolism
Specific function:
Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (By similarity). Required for adipocyte cell viability and metabolic homeostasis (By similarity).
Gene Name:
SPTLC1
Uniprot ID:
Q3MHG1
Molecular weight:
52788.0
Reactions
Palmityl-CoA + L-Serine → 3-Dehydrosphinganine + Carbon dioxidedetails
General function:
Lipid transport and metabolism
Specific function:
Not Available
Gene Name:
GNPAT
Uniprot ID:
A4IF87
Molecular weight:
77664.0
Reactions
Palmityl-CoA + Glycerol 3-phosphate → Coenzyme A + LPA(16:0/0:0)details
General function:
Involved in carnitine O-palmitoyltransferase activity
Specific function:
Not Available
Gene Name:
CPT1B
Uniprot ID:
Q58DK1
Molecular weight:
88512.0
Reactions
Palmityl-CoA + L-Carnitine → L-Palmitoylcarnitine + Coenzyme Adetails
General function:
Involved in carnitine O-palmitoyltransferase activity
Specific function:
Not Available
Gene Name:
CPT2
Uniprot ID:
Q2KJB7
Molecular weight:
74483.0
Reactions
Palmityl-CoA + L-Carnitine → L-Palmitoylcarnitine + Coenzyme Adetails
General function:
Involved in acyltransferase activity
Specific function:
Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC. Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins. Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum. Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function.
Gene Name:
ZDHHC6
Uniprot ID:
Q2HJ95
Molecular weight:
47531.0
General function:
Involved in acyltransferase activity
Specific function:
The ZDHHC9-GOLGA7 complex is a palmitoyltransferase specific for HRAS and NRAS.
Gene Name:
ZDHHC9
Uniprot ID:
Q58DA8
Molecular weight:
40826.0
General function:
Involved in zinc ion binding
Specific function:
Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane. This affects rapid intracellular signaling by sex hormones via ERK and AKT kinases and the generation of cAMP, but does not affect that mediated by their nuclear receptor (By similarity).
Gene Name:
ZDHHC21
Uniprot ID:
A2VDT6
Molecular weight:
31463.0
General function:
Involved in acyltransferase activity
Specific function:
Catalyzes palmitoylation of Cys residues on target proteins. Catalyzes palmitoylation of Cys residues in the cytoplasmic C-terminus of EGFR, and modulates the duration of EGFR signaling by modulating palmitoylation-dependent EGFR internalization and degradation. Has a preference for acyl-CoA with C16 fatty acid chains. Can also utilize acyl-CoA with C14 and C18 fatty acid chains.
Gene Name:
ZDHHC20
Uniprot ID:
Q0VC89
Molecular weight:
41907.0
General function:
Involved in acyltransferase activity
Specific function:
Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (By similarity). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (By similarity). May play a role in DNA damage response (By similarity). May be involved in apoptosis regulation (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity).
Gene Name:
ZDHHC16
Uniprot ID:
Q58CU4
Molecular weight:
43614.0
General function:
Involved in acyltransferase activity
Specific function:
Not Available
Gene Name:
ZDHHC4
Uniprot ID:
Q58DT3
Molecular weight:
39710.0
General function:
Coenzyme transport and metabolism
Specific function:
Not Available
Gene Name:
GCAT
Uniprot ID:
Q0P5L8
Molecular weight:
45166.0
Reactions
Palmityl-CoA + L-Serine → 3-Dehydrosphinganine + Carbon dioxidedetails
General function:
Lipid transport and metabolism
Specific function:
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis.
Gene Name:
GPAM
Uniprot ID:
Q5GJ77
Molecular weight:
93144.0
Reactions
Glycerol 3-phosphate + Palmityl-CoA → LPA(16:0/0:0) + Coenzyme Adetails
General function:
Lipid transport and metabolism
Specific function:
Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.
Gene Name:
ACSBG1
Uniprot ID:
Q2KHW5
Molecular weight:
80585.0
Reactions
Palmitic acid + Adenosine triphosphate + Coenzyme A → Palmityl-CoA + Adenosine monophosphate + Pyrophosphatedetails
General function:
Involved in palmitoyl-(protein) hydrolase activity
Specific function:
Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons.
Gene Name:
PPT1
Uniprot ID:
P45478
Molecular weight:
34142.0
Reactions
Palmityl-CoA + Water → Palmitic acid + Coenzyme Adetails
General function:
Not Available
Specific function:
Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. In liver, plays a role in esterifying exogenous fatty acids to glycerol.
Gene Name:
DGAT1
Uniprot ID:
Q8MK44
Molecular weight:
55602.0
Reactions
DG(14:0/14:0/0:0) + Palmityl-CoA → TG(14:0/14:0/16:0) + Coenzyme Adetails
DG(14:0/15:0/0:0) + Palmityl-CoA → TG(14:0/15:0/16:0) + Coenzyme Adetails
DG(14:0/16:0/0:0) + Palmityl-CoA → TG(14:0/16:0/16:0) + Coenzyme Adetails
DG(14:1(9Z)/14:1(9Z)/0:0) + Palmityl-CoA → TG(14:1(9Z)/14:1(9Z)/16:0)[iso3] + Coenzyme Adetails
DG(15:0/15:0/0:0) + Palmityl-CoA → TG(15:0/15:0/16:0) + Coenzyme Adetails
DG(15:0/16:0/0:0) + Palmityl-CoA → TG(15:0/16:0/16:0) + Coenzyme Adetails
DG(16:0/16:0/0:0) + Palmityl-CoA → TG(16:0/16:0/16:0)[iso] + Coenzyme Adetails
DG(20:0/13:0/0:0) + Palmityl-CoA → TG(20:0/13:0/16:0) + Coenzyme Adetails
DG(20:0/8:0/0:0) + Palmityl-CoA → TG(20:0/8:0/16:0) + Coenzyme Adetails
DG(20:0/12:0/0:0) + Palmityl-CoA → TG(20:0/12:0/16:0) + Coenzyme Adetails
DG(19:0/22:0/0:0) + Palmityl-CoA → TG(19:0/22:0/16:0) + Coenzyme Adetails
DG(20:0/17:0/0:0) + Palmityl-CoA → TG(20:0/17:0/16:0) + Coenzyme Adetails
DG(19:0/21:0/0:0) + Palmityl-CoA → TG(19:0/21:0/16:0) + Coenzyme Adetails
DG(21:0/14:0/0:0) + Palmityl-CoA → TG(21:0/14:0/16:0) + Coenzyme Adetails
DG(21:0/8:0/0:0) + Palmityl-CoA → TG(21:0/8:0/16:0) + Coenzyme Adetails
DG(21:0/13:0/0:0) + Palmityl-CoA → TG(21:0/13:0/16:0) + Coenzyme Adetails
DG(21:0/16:0/0:0) + Palmityl-CoA → TG(21:0/16:0/16:0) + Coenzyme Adetails
DG(21:0/12:0/0:0) + Palmityl-CoA → TG(21:0/12:0/16:0) + Coenzyme Adetails
DG(22:0/17:0/0:0) + Palmityl-CoA → TG(22:0/17:0/16:0) + Coenzyme Adetails
DG(22:0/8:0/0:0) + Palmityl-CoA → TG(22:0/8:0/16:0) + Coenzyme Adetails
DG(22:0/13:0/0:0) + Palmityl-CoA → TG(22:0/13:0/16:0) + Coenzyme Adetails
DG(8:0/12:0/0:0) + Palmityl-CoA → TG(8:0/12:0/16:0) + Coenzyme Adetails
DG(10:0/13:0/0:0) + Palmityl-CoA → TG(10:0/13:0/16:0) + Coenzyme Adetails
DG(10:0/16:0/0:0) + Palmityl-CoA → TG(10:0/16:0/16:0) + Coenzyme Adetails
DG(10:0/19:0/0:0) + Palmityl-CoA → TG(10:0/19:0/16:0) + Coenzyme Adetails
DG(8:0/16:0/0:0) + Palmityl-CoA → TG(8:0/16:0/16:0) + Coenzyme Adetails
DG(8:0/17:0/0:0) + Palmityl-CoA → TG(8:0/17:0/16:0) + Coenzyme Adetails
DG(19:0/a-21:0/0:0) + Palmityl-CoA → TG(19:0/a-21:0/16:0) + Coenzyme Adetails
DG(19:0/a-25:0/0:0) + Palmityl-CoA → TG(19:0/a-25:0/16:0) + Coenzyme Adetails
DG(19:0/i-21:0/0:0) + Palmityl-CoA → TG(19:0/i-21:0/16:0) + Coenzyme Adetails
DG(19:0/i-22:0/0:0) + Palmityl-CoA → TG(19:0/i-22:0/16:0) + Coenzyme Adetails
DG(19:0/i-24:0/0:0) + Palmityl-CoA → TG(19:0/i-24:0/16:0) + Coenzyme Adetails
DG(a-21:0/12:0/0:0) + Palmityl-CoA → TG(a-21:0/12:0/16:0)[rac] + Coenzyme Adetails
DG(a-21:0/13:0/0:0) + Palmityl-CoA → TG(a-21:0/13:0/16:0)[rac] + Coenzyme Adetails
DG(a-21:0/14:0/0:0) + Palmityl-CoA → TG(a-21:0/14:0/16:0)[rac] + Coenzyme Adetails
DG(a-21:0/15:0/0:0) + Palmityl-CoA → TG(a-21:0/15:0/16:0)[rac] + Coenzyme Adetails
DG(a-21:0/16:0/0:0) + Palmityl-CoA → TG(a-21:0/16:0/16:0)[rac] + Coenzyme Adetails
DG(a-21:0/a-21:0/0:0) + Palmityl-CoA → TG(a-21:0/a-21:0/16:0)[rac] + Coenzyme Adetails
DG(a-25:0/12:0/0:0) + Palmityl-CoA → TG(a-25:0/12:0/16:0)[rac] + Coenzyme Adetails
DG(a-25:0/13:0/0:0) + Palmityl-CoA → TG(a-25:0/13:0/16:0)[rac] + Coenzyme Adetails
DG(a-25:0/14:0/0:0) + Palmityl-CoA → TG(a-25:0/14:0/16:0)[rac] + Coenzyme Adetails
DG(a-25:0/15:0/0:0) + Palmityl-CoA → TG(a-25:0/15:0/16:0)[rac] + Coenzyme Adetails
DG(a-25:0/16:0/0:0) + Palmityl-CoA → TG(a-25:0/16:0/16:0)[rac] + Coenzyme Adetails
DG(a-25:0/a-25:0/0:0) + Palmityl-CoA → TG(a-25:0/a-25:0/16:0)[rac] + Coenzyme Adetails
DG(i-19:0/i-21:0/0:0) + Palmityl-CoA → TG(i-19:0/i-21:0/16:0) + Coenzyme Adetails
DG(i-19:0/i-22:0/0:0) + Palmityl-CoA → TG(i-19:0/i-22:0/16:0) + Coenzyme Adetails
DG(i-19:0/i-24:0/0:0) + Palmityl-CoA → TG(i-19:0/i-24:0/16:0) + Coenzyme Adetails
DG(i-20:0/12:0/0:0) + Palmityl-CoA → TG(i-20:0/12:0/16:0) + Coenzyme Adetails
DG(i-20:0/13:0/0:0) + Palmityl-CoA → TG(i-20:0/13:0/16:0) + Coenzyme Adetails
DG(i-20:0/14:0/0:0) + Palmityl-CoA → TG(i-20:0/14:0/16:0) + Coenzyme Adetails
DG(i-20:0/15:0/0:0) + Palmityl-CoA → TG(i-20:0/15:0/16:0) + Coenzyme Adetails
DG(i-20:0/16:0/0:0) + Palmityl-CoA → TG(i-20:0/16:0/16:0) + Coenzyme Adetails
DG(i-20:0/i-20:0/0:0) + Palmityl-CoA → TG(i-20:0/i-20:0/16:0) + Coenzyme Adetails
DG(i-21:0/12:0/0:0) + Palmityl-CoA → TG(i-21:0/12:0/16:0) + Coenzyme Adetails
DG(i-21:0/13:0/0:0) + Palmityl-CoA → TG(i-21:0/13:0/16:0) + Coenzyme Adetails
DG(i-21:0/14:0/0:0) + Palmityl-CoA → TG(i-21:0/14:0/16:0) + Coenzyme Adetails
DG(i-21:0/15:0/0:0) + Palmityl-CoA → TG(i-21:0/15:0/16:0) + Coenzyme Adetails
DG(i-21:0/16:0/0:0) + Palmityl-CoA → TG(i-21:0/16:0/16:0) + Coenzyme Adetails
DG(i-21:0/i-21:0/0:0) + Palmityl-CoA → TG(i-21:0/i-21:0/16:0) + Coenzyme Adetails
DG(i-22:0/12:0/0:0) + Palmityl-CoA → TG(i-22:0/12:0/16:0) + Coenzyme Adetails
DG(i-22:0/13:0/0:0) + Palmityl-CoA → TG(i-22:0/13:0/16:0) + Coenzyme Adetails
DG(i-22:0/14:0/0:0) + Palmityl-CoA → TG(i-22:0/14:0/16:0) + Coenzyme Adetails
DG(i-22:0/15:0/0:0) + Palmityl-CoA → TG(i-22:0/15:0/16:0) + Coenzyme Adetails
DG(i-22:0/16:0/0:0) + Palmityl-CoA → TG(i-22:0/16:0/16:0) + Coenzyme Adetails
DG(i-22:0/i-22:0/0:0) + Palmityl-CoA → TG(i-22:0/i-22:0/16:0) + Coenzyme Adetails
DG(i-24:0/12:0/0:0) + Palmityl-CoA → TG(i-24:0/12:0/16:0) + Coenzyme Adetails
DG(i-24:0/13:0/0:0) + Palmityl-CoA → TG(i-24:0/13:0/16:0) + Coenzyme Adetails
DG(i-24:0/14:0/0:0) + Palmityl-CoA → TG(i-24:0/14:0/16:0) + Coenzyme Adetails
DG(i-24:0/15:0/0:0) + Palmityl-CoA → TG(i-24:0/15:0/16:0) + Coenzyme Adetails
DG(i-24:0/16:0/0:0) + Palmityl-CoA → TG(i-24:0/16:0/16:0) + Coenzyme Adetails
DG(i-24:0/i-24:0/0:0) + Palmityl-CoA → TG(i-24:0/i-24:0/16:0) + Coenzyme Adetails
General function:
Not Available
Specific function:
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.
Gene Name:
AGPAT1
Uniprot ID:
Q95JH2
Molecular weight:
32005.0
Reactions
LPA(16:0/0:0) + Palmityl-CoA → Coenzyme A + PA(16:0/16:0)details
Palmityl-CoA + LPA(16:0/0:0) → PA(16:0/16:0) + Coenzyme Adetails
General function:
Not Available
Specific function:
Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone (By similarity). Exhibits high acyl-CoA specificity for polyunsaturated fatty acyl-CoA, especially docosahexaenoyl-CoA (22:6-CoA, DHA-CoA) (By similarity).
Gene Name:
AGPAT4
Uniprot ID:
Q5E9R2
Molecular weight:
43907.0
Reactions
LPA(16:0/0:0) + Palmityl-CoA → PA(16:0/16:0) + Coenzyme Adetails