Showing metabocard for Tetrahydrofolic acid (BMDB0001846)

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs. Associates with mitochondrial DNA. In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex.

Gene Name:

SHMT2

Uniprot ID:

Q3SZ20

Molecular weight:

55605.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Interconversion of serine and glycine.

Gene Name:

SHMT1

Uniprot ID:

Q5E9P9

Molecular weight:

52978.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2.

Gene Name:

MTHFD1L

Uniprot ID:

Q0VCR7

Molecular weight:

105227.0

General function:

Coenzyme transport and metabolism

Specific function:

Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.

Gene Name:

FPGS

Uniprot ID:

A6H751

Molecular weight:

64900.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity).

Gene Name:

MTR

Uniprot ID:

Q4JIJ3

Molecular weight:

140478.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis.

Gene Name:

ATIC

Uniprot ID:

Q0VCK0

Molecular weight:

64483.0

Reactions

General function:

Translation, ribosomal structure and biogenesis

Specific function:

Formylates methionyl-tRNA in mitochondria. A single tRNA(Met) gene gives rise to both an initiator and an elongator species via an unknown mechanism.

Gene Name:

MTFMT

Uniprot ID:

O77480

Molecular weight:

43620.0

Reactions

General function:

Nucleotide transport and metabolism

Specific function:

Not Available

Gene Name:

GART

Uniprot ID:

Q59A32

Molecular weight:

107907.0

Reactions

General function:

Energy production and conversion

Specific function:

Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal. May have a broader specificity and oxidize other aldehydes in vivo.

Gene Name:

ALDH1A1

Uniprot ID:

P48644

Molecular weight:

54806.0

Reactions

General function:

Amino acid transport and metabolism

Specific function:

The glycine cleavage system catalyzes the degradation of glycine.

Gene Name:

AMT

Uniprot ID:

P25285

Molecular weight:

42869.0

General function:

Coenzyme transport and metabolism

Specific function:

Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFR2 (By similarity).

Gene Name:

DHFR

Uniprot ID:

P00376

Molecular weight:

21604.0

Reactions

General function:

Not Available

Specific function:

Not Available

Gene Name:

FTCD

Uniprot ID:

F1MNA6

Molecular weight:

60005.0

Reactions