Showing metabocard for Hydrogen (BMDB0001362)

General function:

Coenzyme transport and metabolism

Specific function:

Catalyzes the ferrous insertion into protoporphyrin IX.

Gene Name:

FECH

Uniprot ID:

P22600

Molecular weight:

46935.0

Reactions

General function:

Energy production and conversion

Specific function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Gene Name:

ATP5F1B

Uniprot ID:

P00829

Molecular weight:

56284.0

General function:

Involved in ATP binding

Specific function:

This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA (By similarity). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity).

Gene Name:

PCCB

Uniprot ID:

Q2TBR0

Molecular weight:

58311.0

Reactions

General function:

Energy production and conversion

Specific function:

Catalyzes the cofactor-independent reversible oxidation of gamma-hydroxybutyrate (GHB) to succinic semialdehyde (SSA) coupled to reduction of 2-ketoglutarate (2-KG) to D-2-hydroxyglutarate (D-2-HG). L-3-hydroxybutyrate (L-3-OHB) is also a substrate for HOT when using 2-KG as hydrogen acceptor, resulting in the formation of D-2-HG (By similarity).

Gene Name:

ADHFE1

Uniprot ID:

A6QP15

Molecular weight:

50343.0

General function:

Involved in ATP binding

Specific function:

Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate (By similarity).

Gene Name:

PC

Uniprot ID:

Q29RK2

Molecular weight:

129698.0

Reactions

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

MDH1

Uniprot ID:

Q3T145

Molecular weight:

36438.0

Reactions

General function:

Involved in hydrogen ion transmembrane transporter acti

Specific function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Gene Name:

ATP5MF

Uniprot ID:

Q28851

Molecular weight:

10297.0

General function:

Energy production and conversion

Specific function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Gene Name:

ATP5MC1

Uniprot ID:

P32876

Molecular weight:

14223.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

ATP6

Uniprot ID:

Q45MM4

Molecular weight:

24774.0

General function:

Involved in hydrogen ion transmembrane transporter acti

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

Q85E89

Molecular weight:

5834.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

ATP6V0B

Uniprot ID:

A1XE98

Molecular weight:

9769.0

General function:

Involved in hydrogen ion transmembrane transporter acti

Specific function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Gene Name:

ATP8

Uniprot ID:

Q45MQ1

Molecular weight:

7967.0

General function:

Energy production and conversion

Specific function:

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis. May play a role in cilium biogenesis through regulation of the transport and the localization of proteins to the cilium (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity).

Gene Name:

ATP6V0D1

Uniprot ID:

P61420

Molecular weight:

40329.0

General function:

Energy production and conversion

Specific function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.

Gene Name:

ATP5MC3

Uniprot ID:

Q3ZC75

Molecular weight:

14693.0

General function:

Involved in hydrogen ion transmembrane transporter acti

Specific function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Gene Name:

ATP5PD

Uniprot ID:

P13620

Molecular weight:

18692.0

General function:

Energy production and conversion

Specific function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.

Gene Name:

MT-ATP6

Uniprot ID:

P00847

Molecular weight:

24788.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

ATP6

Uniprot ID:

Q7JAT1

Molecular weight:

24788.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

ATP6

Uniprot ID:

Q45LV1

Molecular weight:

24696.0

General function:

Energy production and conversion

Specific function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites. Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions (By similarity).

Gene Name:

ATP5F1A

Uniprot ID:

P19483

Molecular weight:

59720.0

General function:

Energy production and conversion

Specific function:

Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Gene Name:

ATP6V1B2

Uniprot ID:

P31408

Molecular weight:

56577.0

General function:

Involved in ATP synthesis coupled proton transport

Specific function:

Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Gene Name:

ATP6V1C1

Uniprot ID:

P21282

Molecular weight:

43986.0

General function:

Involved in hydrogen ion transmembrane transporter acti

Specific function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Gene Name:

ATP8

Uniprot ID:

Q7JAT2

Molecular weight:

7937.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

Q862C2

Molecular weight:

14150.0

General function:

Involved in hydrogen ion transmembrane transporter acti

Specific function:

Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.

Gene Name:

DMAC2L

Uniprot ID:

P22027

Molecular weight:

23293.0

General function:

Energy production and conversion

Specific function:

Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity).

Gene Name:

ATP6V0D2

Uniprot ID:

Q2KJB6

Molecular weight:

40497.0

General function:

Energy production and conversion

Specific function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Gene Name:

ATP5F1C

Uniprot ID:

P05631

Molecular weight:

33072.0

General function:

Energy production and conversion

Specific function:

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Gene Name:

ATP6V1F

Uniprot ID:

Q28029

Molecular weight:

13398.0

General function:

Energy production and conversion

Specific function:

Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH (By similarity). In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity).

Gene Name:

ATP6V0A2

Uniprot ID:

O97681

Molecular weight:

98010.0

General function:

Energy production and conversion

Specific function:

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity).

Gene Name:

ATP6V0B

Uniprot ID:

Q2TA24

Molecular weight:

21519.0

General function:

Involved in hydrogen ion transmembrane transporter acti

Specific function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).

Gene Name:

MT-ATP8

Uniprot ID:

P03929

Molecular weight:

7937.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

ATP6

Uniprot ID:

B1NZT1

Molecular weight:

24787.0

General function:

Involved in hydrogen ion transmembrane transporter acti

Specific function:

Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Gene Name:

ATP6V0E1

Uniprot ID:

P81103

Molecular weight:

9304.0

General function:

Energy production and conversion

Specific function:

Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Gene Name:

ATP6V1E1

Uniprot ID:

P11019

Molecular weight:

26139.0

General function:

Involved in hydrogen ion transmembrane transporter acti

Specific function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Gene Name:

ATP5MG

Uniprot ID:

Q28852

Molecular weight:

11417.0

General function:

Involved in hydrogen ion transmembrane transporter acti

Specific function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Gene Name:

ATP8

Uniprot ID:

Q45LL1

Molecular weight:

7938.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

ATP6

Uniprot ID:

B1P0J1

Molecular weight:

24803.0

General function:

Energy production and conversion

Specific function:

Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Gene Name:

ATP6V1B1

Uniprot ID:

P31407

Molecular weight:

56747.0

General function:

Energy production and conversion

Specific function:

Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity).

Gene Name:

ATP6V0A1

Uniprot ID:

Q29466

Molecular weight:

96302.0

General function:

Involved in hydrogen ion transmembrane transporter acti

Specific function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Gene Name:

ATP5ME

Uniprot ID:

Q00361

Molecular weight:

8321.0

General function:

Involved in hydrogen ion transmembrane transporter acti

Specific function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Gene Name:

ATP5PB

Uniprot ID:

P13619

Molecular weight:

28822.0

General function:

Involved in hydrogen ion transmembrane transporter acti

Specific function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.

Gene Name:

ATP8

Uniprot ID:

B1P0L6

Molecular weight:

7921.0

General function:

Involved in proton transport

Specific function:

Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity).

Gene Name:

ATP6V1G1

Uniprot ID:

P79251

Molecular weight:

13682.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

ATP6

Uniprot ID:

B1NZU4

Molecular weight:

24776.0

General function:

Involved in hydrogen ion transporting ATP synthase acti

Specific function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Gene Name:

ATP5F1E

Uniprot ID:

P05632

Molecular weight:

5783.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

ATP6

Uniprot ID:

Q3L5Q7

Molecular weight:

24815.0

General function:

Energy production and conversion

Specific function:

Produces ATP from ADP in the presence of a proton gradient across the membrane.

Gene Name:

ATP5B

Uniprot ID:

Q0QEM9

Molecular weight:

34770.0

General function:

Energy production and conversion

Specific function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.

Gene Name:

ATP5F1D

Uniprot ID:

P05630

Molecular weight:

17612.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

Not Available

Uniprot ID:

A1XEE3

Molecular weight:

9084.0

General function:

Energy production and conversion

Specific function:

Not Available

Gene Name:

ATP6

Uniprot ID:

B1P0A0

Molecular weight:

24774.0

General function:

Energy production and conversion

Specific function:

Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.

Gene Name:

ATP5PO

Uniprot ID:

P13621

Molecular weight:

23320.0