Showing metabocard for Sodium (BMDB0000588)

IdentificationTaxonomyPhysical propertiesPathwaysSpectraConcentrationsLinksReferencesenzymes (64) Show 64 proteinsXML
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Record Information
Version1.0
Creation Date2016-09-30 22:33:13 UTC
Update Date2020-06-04 22:53:48 UTC
BMDB IDBMDB0000588
Secondary Accession Numbers
  • BMDB00588
Metabolite Identification
Common NameSodium
DescriptionSodium, also known as Na+ or sodium ion, belongs to the class of inorganic compounds known as homogeneous alkali metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkali metal atom. Sodium is a weakly acidic compound (based on its pKa). Sodium exists in all living species, ranging from bacteria to humans.
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
Na(+)ChEBI
Na+ChEBI
SODIUM ionChEBI
Sodium(1+)Kegg
Chemical FormulaNa
Average Molecular Weight22.9898
Monoisotopic Molecular Weight22.989769675
IUPAC Namesodium(1+) ion
Traditional Namesodium(1+) ion
CAS Registry Number7440-23-5
SMILES
[Na+]
InChI Identifier
InChI=1S/Na/q+1
InChI KeyFKNQFGJONOIPTF-UHFFFAOYSA-N
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as homogeneous alkali metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a alkali metal atom.
KingdomInorganic compounds
Super ClassHomogeneous metal compounds
ClassHomogeneous alkali metal compounds
Sub ClassNot Available
Direct ParentHomogeneous alkali metal compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous alkali metal
Molecular FrameworkNot Available
External Descriptors
Ontology
StatusDetected and Quantified
Origin
  • Exogenous
BiofunctionNot Available
ApplicationNot Available
Cellular locations
  • Golgi
  • Peroxisome
Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point97.82 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-0.77ChemAxon
pKa (Strongest Acidic)3.09ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m³·mol⁻¹ChemAxon
Polarizability1.78 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleYesChemAxon
Spectra
Spectra
Spectrum TypeDescriptionSplash Key
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-00di-9000000000-25bf08b0ab99f8116a31View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-00di-9000000000-25bf08b0ab99f8116a31View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-00di-9000000000-25bf08b0ab99f8116a31View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-00di-9000000000-fba837e9c7559de06780View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-00di-9000000000-fba837e9c7559de06780View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-00di-9000000000-fba837e9c7559de06780View in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-00di-9000000000-1d278094c49273af723fView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-00di-9000000000-1d278094c49273af723fView in MoNA
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-00di-9000000000-1d278094c49273af723fView in MoNA
Biological Properties
Cellular Locations
  • Golgi
  • Peroxisome
Biospecimen Locations
  • Blood
  • Kidney
  • Liver
  • Longissimus Thoracis Muscle
  • Milk
  • Ruminal Fluid
  • Semimembranosus Muscle
  • Testis
Pathways
Normal Concentrations
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified141000 uMNot SpecifiedNot Specified
Treated with bovine somatotropin		 details
BloodDetected and Quantified140170 +/- 850 uMNot SpecifiedNot Specified
Left displaced abomasum (LDA)
    • Abdullah BASOGLU,...
 details
BloodDetected and Quantified138600 +/- 880 uMNot SpecifiedNot Specified
Right displaced abomasum (RDA)
    • Abdullah BASOGLU,...
 details
HMDB IDHMDB0000588
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB031052
KNApSAcK IDNot Available
Chemspider ID899
KEGG Compound IDC01330
BioCyc IDNot Available
BiGG ID37376
Wikipedia LinkSodium
METLIN ID3192
PubChem Compound923
PDB IDNot Available
ChEBI ID29101
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Gaucheron F: The minerals of milk. Reprod Nutr Dev. 2005 Jul-Aug;45(4):473-83. doi: 10.1051/rnd:2005030. [PubMed:16045895 ]
  2. Auldist MJ, Walsh BJ, Thomson NA: Seasonal and lactational influences on bovine milk composition in New Zealand. J Dairy Res. 1998 Aug;65(3):401-11. [PubMed:9718493 ]
  3. Gaucheron F: Milk and dairy products: a unique micronutrient combination. J Am Coll Nutr. 2011 Oct;30(5 Suppl 1):400S-9S. [PubMed:22081685 ]
  4. Park, Y. W; Juárez, Manuela ; Ramos, M.; Haenlein, G. F. W. (2007). Park, Y. W; Juárez, Manuela ; Ramos, M.; Haenlein, G. F. W.. Physico-chemical characteristics of goat and sheep milk. Small Ruminant Res.(2007) 68:88-113 doi: 10.1016/j.smallrumres.2006.09.013. Small Ruminant Research.
  5. A. Foroutan et al. (2019). A. Foroutan et al. The Chemical Composition of Commercial Cow's Milk (in preparation). Journal of Agricultural and Food Chemistry.
  6. USDA Food Composition Databases [Link]
  7. Fooddata+, The Technical University of Denmark (DTU) [Link]

Only showing the first 50 proteins. There are 64 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details
1. Sodium/potassium-transporting ATPase subunit alpha-1
General function:
Inorganic ion transport and metabolism
Specific function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.
Gene Name:
ATP1A1
Uniprot ID:
Q08DA1
Molecular weight:
112643.0
Enzyme Details
2. Sodium/potassium-transporting ATPase subunit alpha-2
General function:
Inorganic ion transport and metabolism
Specific function:
This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients (By similarity).
Gene Name:
ATP1A2
Uniprot ID:
A2VDL6
Molecular weight:
112179.0
Enzyme Details
3. DNA polymerase beta
General function:
Replication, recombination and repair
Specific function:
Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases (By similarity).
Gene Name:
POLB
Uniprot ID:
Q27958
Molecular weight:
38267.0
Enzyme Details
4. Ubiquitin-conjugating enzyme E2 E3
General function:
Involved in ATP binding
Specific function:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Participates in the regulation of transepithelial sodium transport in renal cells. May be involved in cell growth arrest.
Gene Name:
UBE2E3
Uniprot ID:
Q2T9X7
Molecular weight:
22913.0
Enzyme Details
5. Protein tyrosine phosphatase type IVA 3
General function:
Signal transduction mechanisms
Specific function:
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II (By similarity).
Gene Name:
PTP4A3
Uniprot ID:
A2VDT1
Molecular weight:
19511.0
Enzyme Details
6. Sodium/potassium-transporting ATPase subunit beta-2
General function:
Involved in potassium ion binding
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-2 subunit is not known.
Gene Name:
ATP1B2
Uniprot ID:
Q28030
Molecular weight:
33401.0
Enzyme Details
7. Sodium/potassium-transporting ATPase subunit beta-3
General function:
Involved in potassium ion binding
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. The exact function of the beta-3 subunit is not known (By similarity).
Gene Name:
ATP1B3
Uniprot ID:
Q3T0C6
Molecular weight:
31521.0
Enzyme Details
8. Sodium/potassium-transporting ATPase subunit gamma
General function:
Involved in ion channel activity
Specific function:
May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.
Gene Name:
FXYD2
Uniprot ID:
Q04645
Molecular weight:
6545.0
Enzyme Details
9. Prostaglandin E2 receptor EP3 subtype
General function:
Not Available
Specific function:
Receptor for prostaglandin E2 (PGE2) (PubMed:8396726). The various isoforms have identical ligand binding properties but interact with different second messenger systems: isoform EP3A couples to G(i)/G(o) proteins; isoform EP3B and isoform EP3C couple to G(s), and isoform EP3D couples to G(i), G(s) and G(p) (PubMed:8396726). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity).
Gene Name:
PTGER3
Uniprot ID:
P34979
Molecular weight:
46362.0
Enzyme Details
10. Solute carrier family 10 (Sodium/bile acid cotransporter family), member 4
General function:
Involved in bile acid:sodium symporter activity
Specific function:
Not Available
Gene Name:
SLC10A4
Uniprot ID:
A0JNQ1
Molecular weight:
47122.0
Enzyme Details
11. SLC12A5 protein
General function:
Involved in potassium:chloride symporter activity
Specific function:
Not Available
Gene Name:
SLC12A5
Uniprot ID:
A8KC65
Molecular weight:
129418.0
Enzyme Details
12. Na-K-Cl cotransporter
General function:
Involved in cation:chloride symporter activity
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
O18978
Molecular weight:
130394.0
Enzyme Details
13. Sodium chloride cotransporter
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
O97740
Molecular weight:
17189.0
Enzyme Details
14. Sodium/myo-inositol cotransporter 2
General function:
Involved in sodium ion binding
Specific function:
Involved in the sodium-dependent cotransport of myo-inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D-xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.
Gene Name:
SLC5A11
Uniprot ID:
Q3ZC26
Molecular weight:
73957.0
Enzyme Details
15. Na+/myo-inositol cotransporter
General function:
Involved in transporter activity
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
O19135
Molecular weight:
79621.0
Enzyme Details
16. Sodium- and chloride-dependent creatine transporter 1
General function:
Involved in creatine:sodium symporter activity
Specific function:
Required for the uptake of creatine. Plays an important role in supplying creatine to the brain via the blood-brain barrier (By similarity).
Gene Name:
SLC6A8
Uniprot ID:
O18875
Molecular weight:
70676.0
Enzyme Details
17. Sodium iodide symporter
General function:
Not Available
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
B6ZBT4
Molecular weight:
7085.0
Enzyme Details
18. Truncated sodium iodide symporter
General function:
Involved in sodium:iodide symporter activity
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
B2CSJ0
Molecular weight:
7533.0
Enzyme Details
19. Sodium-coupled neutral amino acid transporter 2
General function:
Amino acid transport and metabolism
Specific function:
Functions as a sodium-dependent amino acid transporter. Mediates the saturable, pH-sensitive and electrogenic cotransport of neutral amino acids and sodium ions with a stoichiometry of 1:1. May function in the transport of amino acids at the blood-brain barrier and in the supply of maternal nutrients to the fetus through the placenta (By similarity).
Gene Name:
SLC38A2
Uniprot ID:
A2VE31
Molecular weight:
56214.0
Enzyme Details
20. Solute carrier family 5 (Choline transporter), member 7
General function:
Amino acid transport and metabolism
Specific function:
Not Available
Gene Name:
SLC5A7
Uniprot ID:
Q2KI26
Molecular weight:
63385.0
Enzyme Details
21. Sodium-coupled neutral amino acid transporter 5
General function:
Amino acid transport and metabolism
Specific function:
Functions as a sodium-dependent amino acid transporter which countertransport protons. Mediates the saturable, pH-sensitive, and electrogenic cotransport of several neutral amino acids including glycine, asparagine, alanine, serine, glutamine and histidine with sodium (By similarity).
Gene Name:
SLC38A5
Uniprot ID:
Q5E9S9
Molecular weight:
51958.0
Enzyme Details
22. Solute carrier family 13 (Sodium-dependent dicarboxylate transporter), member 2
General function:
Inorganic ion transport and metabolism
Specific function:
Not Available
Gene Name:
SLC13A2
Uniprot ID:
Q3SYV8
Molecular weight:
64980.0
Enzyme Details
23. Solute carrier family 13 (Sodium-dependent dicarboxylate transporter), member 3
General function:
Inorganic ion transport and metabolism
Specific function:
Not Available
Gene Name:
SLC13A3
Uniprot ID:
A1A4I3
Molecular weight:
66657.0
Enzyme Details
24. Putative sodium-glucose cotransporter
General function:
Involved in glucose transmembrane transporter activity
Specific function:
Not Available
Gene Name:
sglt1
Uniprot ID:
Q9TTR6
Molecular weight:
34774.0
Enzyme Details
25. Na+/glucose cotransporter
General function:
Involved in glucose transmembrane transporter activity
Specific function:
Not Available
Gene Name:
SGLT1
Uniprot ID:
Q8MKB7
Molecular weight:
73076.0
Enzyme Details
26. Sodium-dependent glucose transporter SGLT-I
General function:
Involved in glucose:sodium symporter activity
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
Q95JG8
Molecular weight:
20235.0
Enzyme Details
27. Amiloride-sensitive sodium channel subunit alpha
General function:
Involved in amiloride-sensitive sodium channel activity
Specific function:
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception.
Gene Name:
SCNN1A
Uniprot ID:
P55270
Molecular weight:
73793.0
Enzyme Details
28. Amiloride-sensitive sodium channel subunit beta
General function:
Involved in amiloride-sensitive sodium channel activity
Specific function:
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Gene Name:
SCNN1B
Uniprot ID:
A5D7U4
Molecular weight:
72677.0
Enzyme Details
29. Sodium channel subunit beta-4
General function:
Not Available
Specific function:
Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom (By similarity).
Gene Name:
SCN4B
Uniprot ID:
Q08E08
Molecular weight:
25144.0
Enzyme Details
30. Solute carrier family 10 (Sodium/bile acid cotransporter family), member 1
General function:
Involved in bile acid:sodium symporter activity
Specific function:
Not Available
Gene Name:
SLC10A1
Uniprot ID:
Q2KJ85
Molecular weight:
40531.0
Enzyme Details
31. Sodium channel protein
General function:
Involved in voltage-gated sodium channel activity
Specific function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
Gene Name:
Not Available
Uniprot ID:
Q8WMP8
Molecular weight:
227894.0
Enzyme Details
32. Sodium-driven chloride bicarbonate exchanger
General function:
Involved in inorganic anion exchanger activity
Specific function:
Sodium/bicarbonate cotransporter which plays an important role in regulating intracellular pH (By similarity). Has been shown to act as a sodium/bicarbonate cotransporter in exchange for intracellular chloride (By similarity). Has also been shown to act as a sodium/biocarbonate cotransporter which does not couple net influx of bicarbonate to net efflux of chloride, with the observed chloride efflux being due to chloride self-exchange (By similarity). Controls neuronal pH and may contribute to the secretion of cerebrospinal fluid (By similarity). Reduces the excitability of CA1 pyramidal neurons and modulates short-term synaptic plasticity (By similarity). Required in retinal cells to maintain normal pH which is necessary for normal vision (By similarity). In the kidney, likely to mediate bicarbonate reclamation in the apical membrane of the proximal tubules (By similarity).
Gene Name:
SLC4A10
Uniprot ID:
Q32LP4
Molecular weight:
125776.0
Enzyme Details
33. Sodium/calcium exchanger 1
General function:
Inorganic ion transport and metabolism
Specific function:
Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1416984). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions.
Gene Name:
SLC8A1
Uniprot ID:
P48765
Molecular weight:
108027.0
Enzyme Details
34. Vesicular glutamate transporter 1
General function:
Carbohydrate transport and metabolism
Specific function:
Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate (By similarity).
Gene Name:
SLC17A7
Uniprot ID:
A4FV52
Molecular weight:
61651.0
Enzyme Details
35. ATPase, Na+/K+ transporting, beta 1 polypeptide
General function:
Involved in protein binding
Specific function:
Not Available
Gene Name:
ATP1B1
Uniprot ID:
Q3ZCH8
Molecular weight:
15393.0
Enzyme Details
36. Sodium/hydrogen exchanger 1
General function:
Inorganic ion transport and metabolism
Specific function:
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
Gene Name:
SLC9A1
Uniprot ID:
Q28036
Molecular weight:
91017.0
Enzyme Details
37. Sodium-dependent phosphate transporter 2
General function:
Inorganic ion transport and metabolism
Specific function:
Sodium-phosphate symporter which seems to play a fundamental housekeeping role in phosphate transport by absorbing phosphate from interstitial fluid for normal cellular functions such as cellular metabolism, signal transduction, and nucleic acid and lipid synthesis. In vitro, sodium-dependent phosphate uptake is not significantly affected by acidic and alkaline conditions, however sodium-independent phosphate uptake occurs at acidic conditions. May play a role in extracellular matrix, cartilage calcification and vascular calcification. Functions as a retroviral receptor (By similarity).
Gene Name:
SLC20A2
Uniprot ID:
A1A4I1
Molecular weight:
69610.0
Enzyme Details
38. Electrogenic sodium bicarbonate cotransporter 1
General function:
Involved in inorganic anion exchanger activity
Specific function:
Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.
Gene Name:
SLC4A4
Uniprot ID:
Q9GL77
Molecular weight:
121331.0
Enzyme Details
39. Sodium/hydrogen exchanger
General function:
Inorganic ion transport and metabolism
Specific function:
Not Available
Gene Name:
SLC9A9
Uniprot ID:
Q0VD46
Molecular weight:
72334.0
Enzyme Details
40. Sodium proton exchanger
General function:
Inorganic ion transport and metabolism
Specific function:
Not Available
Gene Name:
Not Available
Uniprot ID:
O97738
Molecular weight:
15971.0
Enzyme Details
41. Solute carrier family 13 (Sodium/sulfate symporters), member 4
General function:
Inorganic ion transport and metabolism
Specific function:
Not Available
Gene Name:
SLC13A4
Uniprot ID:
Q08E60
Molecular weight:
68956.0
Enzyme Details
42. Sodium-coupled monocarboxylate transporter 2
General function:
Amino acid transport and metabolism
Specific function:
Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D-hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina. Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate (By similarity).
Gene Name:
SLC5A12
Uniprot ID:
A7MBD8
Molecular weight:
67410.0
Enzyme Details
43. P3 protein
General function:
Involved in bile acid:sodium symporter activity
Specific function:
The ubiquitous expression and the conservation of the sequence in distant animal species suggest that the gene codes for a protein with housekeeping functions.
Gene Name:
SLC10A3
Uniprot ID:
Q0V8N6
Molecular weight:
50656.0
Enzyme Details
44. Solute carrier family 5 (Sodium-dependent vitamin transporter), member 6
General function:
Amino acid transport and metabolism
Specific function:
Not Available
Gene Name:
SLC5A6
Uniprot ID:
A1L530
Molecular weight:
68814.0
Enzyme Details
45. Sodium/potassium/calcium exchanger 1
General function:
Inorganic ion transport and metabolism
Specific function:
Critical component of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness. Light causes a rapid lowering of cytosolic free calcium in the outer segment of both retinal rod and cone photoreceptors and the light-induced lowering of calcium is caused by extrusion via this protein which plays a key role in the process of light adaptation. Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+) (By similarity).
Gene Name:
SLC24A1
Uniprot ID:
Q28139
Molecular weight:
131614.0
Enzyme Details
46. Protein ATP1B4
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
May act as a transcriptional coregulator during muscle development through its interaction with SNW1. Has lost its ancestral function as a Na,K-ATPase beta-subunit (By similarity).
Gene Name:
ATP1B4
Uniprot ID:
A7MB71
Molecular weight:
41473.0
Enzyme Details
47. Putative sodium-coupled neutral amino acid transporter 11
General function:
Amino acid transport and metabolism
Specific function:
Putative sodium-dependent amino acid/proton antiporter.
Gene Name:
SLC38A11
Uniprot ID:
Q5EA97
Molecular weight:
50745.0
Enzyme Details
48. Putative sodium-coupled neutral amino acid transporter 7
General function:
Amino acid transport and metabolism
Specific function:
Mediates sodium-dependent transport of amino acids, preferentially L-glutamine.
Gene Name:
SLC38A7
Uniprot ID:
A7E3U5
Molecular weight:
49853.0
Enzyme Details
49. Na+/glucose cotransporter 2
General function:
Involved in transporter activity
Specific function:
Not Available
Gene Name:
SLC5A2
Uniprot ID:
Q6XUI1
Molecular weight:
73417.0
Enzyme Details
50. Sodium/potassium-transporting ATPase subunit beta
General function:
Involved in sodium:potassium-exchanging ATPase activity
Specific function:
This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.
Gene Name:
ATP1B2
Uniprot ID:
A6QLL5
Molecular weight:
33406.0

Only showing the first 50 proteins. There are 64 proteins in total.

Show all enzymes and transporters