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Showing metabocard for FAD (BMDB0001248)
| Record Information | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Version | 1.0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Creation Date | 2016-09-30 22:43:02 UTC | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Update Date | 2020-05-21 16:28:35 UTC | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| BMDB ID | BMDB0001248 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Secondary Accession Numbers |
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| Metabolite Identification | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Common Name | FAD | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Description | FAD, also known as adeflavin or flamitajin b, belongs to the class of organic compounds known as flavin nucleotides. These are nucleotides containing a flavin moiety. Flavin is a compound that contains the tricyclic isoalloxazine ring system, which bears 2 oxo groups at the 2- and 4-positions. FAD is a drug which is used to treat eye diseases caused by vitamin b2 deficiency, such as keratitis and blepharitis. FAD is a strong basic compound (based on its pKa). FAD exists in all living species, ranging from bacteria to humans. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Structure |  | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Synonyms |
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| Chemical Formula | C27H33N9O15P2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Average Molecular Weight | 785.5497 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Monoisotopic Molecular Weight | 785.157134455 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IUPAC Name | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Traditional Name | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CAS Registry Number | 146-14-5 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SMILES | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InChI Identifier | InChI=1S/C27H33N9O15P2/c1-10-3-12-13(4-11(10)2)35(24-18(32-12)25(42)34-27(43)33-24)5-14(37)19(39)15(38)6-48-52(44,45)51-53(46,47)49-7-16-20(40)21(41)26(50-16)36-9-31-17-22(28)29-8-30-23(17)36/h3-4,8-9,14-16,19-21,26,37-41H,5-7H2,1-2H3,(H,44,45)(H,46,47)(H2,28,29,30)(H,34,42,43)/t14-,15+,16+,19-,20+,21+,26+/m0/s1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InChI Key | VWWQXMAJTJZDQX-UYBVJOGSSA-N | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Chemical Taxonomy | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Description | belongs to the class of organic compounds known as flavin nucleotides. These are nucleotides containing a flavin moiety. Flavin is a compound that contains the tricyclic isoalloxazine ring system, which bears 2 oxo groups at the 2- and 4-positions. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kingdom | Organic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Super Class | Nucleosides, nucleotides, and analogues | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Class | Flavin nucleotides | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sub Class | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Direct Parent | Flavin nucleotides | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Alternative Parents |
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| Substituents |
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| Molecular Framework | Aromatic heteropolycyclic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| External Descriptors |
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| Ontology | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Status | Detected but not Quantified | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Origin |
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| Biofunction | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Application | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cellular locations |
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| Physical Properties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| State | Solid | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spectra | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spectra |
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| Biological Properties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cellular Locations |
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| Biospecimen Locations |
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| Pathways |
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| Normal Concentrations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Abnormal Concentrations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Not Available | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| External Links | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| HMDB ID | HMDB0001248 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DrugBank ID | DB03147 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Phenol Explorer Compound ID | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| FooDB ID | FDB022511 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| KNApSAcK ID | C00001500 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Chemspider ID | 559059 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| KEGG Compound ID | C00016 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| BioCyc ID | FAD | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| BiGG ID | 33521 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikipedia Link | Flavin_adenine_dinucleotide | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| METLIN ID | 6106 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PubChem Compound | 643975 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PDB ID | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ChEBI ID | 16238 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Synthesis Reference | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Material Safety Data Sheet (MSDS) | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| General References | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Only showing the first 50 proteins. There are 84 proteins in total.
Enzymes
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
- Gene Name:
- NOS3
- Uniprot ID:
- P29473
- Molecular weight:
- 133287.0
- General function:
- Coenzyme transport and metabolism
- Specific function:
- NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS) (By similarity).
- Gene Name:
- CYB5R4
- Uniprot ID:
- Q32LH7
- Molecular weight:
- 59274.0
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such PTGS2/COX2. As component of the iNOS-S100A8/9 transnitrosylase complex involved in the selective inflammatory stimulus-dependent S-nitrosylation of GAPDH implicated in regulation of the GAIT complex activity and probably multiple targets including ANXA5, EZR, MSN and VIM. Involved in inflammation, enhances the synthesis of proinflammatory mediators such as IL6 and IL8.
- Gene Name:
- NOS2
- Uniprot ID:
- Q27995
- Molecular weight:
- 131208.0
- General function:
- Energy production and conversion
- Specific function:
- Not Available
- Gene Name:
- GPD2
- Uniprot ID:
- A6QLU1
- Molecular weight:
- 80763.0
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.
- Gene Name:
- FMO3
- Uniprot ID:
- Q8HYJ9
- Molecular weight:
- 60093.0
- General function:
- Lipid transport and metabolism
- Specific function:
- Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor (By similarity).
- Gene Name:
- GCDH
- Uniprot ID:
- Q2KHZ9
- Molecular weight:
- 48472.0
- General function:
- Involved in electron carrier activity
- Specific function:
- Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration.
- Gene Name:
- PAOX
- Uniprot ID:
- Q865R1
- Molecular weight:
- 56325.0
- General function:
- Energy production and conversion
- Specific function:
- Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (Probable). Can act as a tumor suppressor (By similarity).
- Gene Name:
- SDHA
- Uniprot ID:
- P31039
- Molecular weight:
- 72944.0
- General function:
- Energy production and conversion
- Specific function:
- Accepts electrons from ETF and reduces ubiquinone.
- Gene Name:
- ETFDH
- Uniprot ID:
- Q2KIG0
- Molecular weight:
- 68612.0
- General function:
- Involved in 2-hydroxyglutarate dehydrogenase activity
- Specific function:
- Not Available
- Gene Name:
- L2HGDH
- Uniprot ID:
- A7MBI3
- Molecular weight:
- 51022.0
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of ribonucleoside diphosphate-X compounds among which FAD is the best substrate. Represses IFIH1-mediated cellular antiviral response.
- Gene Name:
- TKFC
- Uniprot ID:
- Q58DK4
- Molecular weight:
- 59124.0
- General function:
- Lipid transport and metabolism
- Specific function:
- Catalyzes the conversion of isovaleryl-CoA/3-methylbutanoyl-CoA to 3-methylbut-2-enoyl-CoA as an intermediate step in the leucine (Leu) catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of other saturated short-chain acyl-CoA thioesters as pentanoyl-CoA, hexenoyl-CoA and butenoyl-CoA.
- Gene Name:
- IVD
- Uniprot ID:
- Q3SZI8
- Molecular weight:
- 46498.0
- General function:
- Energy production and conversion
- Specific function:
- Involved in the control of reactive oxygen species levels and the regulation of mitochondrial redox homeostasis (By similarity). Maintains thioredoxin in a reduced state. May play a role in redox-regulated cell signaling.
- Gene Name:
- TXNRD2
- Uniprot ID:
- Q9N2I8
- Molecular weight:
- 54670.0
- General function:
- Involved in oxygen-dependent protoporphyrinogen oxidase
- Specific function:
- Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.
- Gene Name:
- PPOX
- Uniprot ID:
- P56602
- Molecular weight:
- 50612.0
- General function:
- Energy production and conversion
- Specific function:
- Not Available
- Gene Name:
- TXNRD1
- Uniprot ID:
- O62768
- Molecular weight:
- 54770.0
- General function:
- Nucleotide transport and metabolism
- Specific function:
- Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.
- Gene Name:
- XDH
- Uniprot ID:
- P80457
- Molecular weight:
- 146790.0
- General function:
- Amino acid transport and metabolism
- Specific function:
- Not Available
- Gene Name:
- DDO
- Uniprot ID:
- P31228
- Molecular weight:
- 37660.0
- General function:
- Nucleotide transport and metabolism
- Specific function:
- Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.
- Gene Name:
- AOX1
- Uniprot ID:
- P48034
- Molecular weight:
- 147611.0
- General function:
- Amino acid transport and metabolism
- Specific function:
- Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.
- Gene Name:
- DPYD
- Uniprot ID:
- Q28007
- Molecular weight:
- 111697.0
- General function:
- Lipid transport and metabolism
- Specific function:
- Short-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA (By similarity). Among the different mitochondrial acyl-CoA dehydrogenases, short-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 4 to 6 carbons long primary chains (PubMed:6712627).
- Gene Name:
- ACADS
- Uniprot ID:
- Q3ZBF6
- Molecular weight:
- 44552.0
- General function:
- Energy production and conversion
- Specific function:
- Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate.
- Gene Name:
- D2HGDH
- Uniprot ID:
- Q1JPD3
- Molecular weight:
- 59056.0
- General function:
- Coenzyme transport and metabolism
- Specific function:
- NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction.
- Gene Name:
- CYB5R1
- Uniprot ID:
- Q3MHW9
- Molecular weight:
- 33861.0
- General function:
- Secondary metabolites biosynthesis, transport and catabolism
- Specific function:
- Probable oxidoreductase.
- Gene Name:
- PYROXD2
- Uniprot ID:
- Q3MHH6
- Molecular weight:
- 62987.0
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- Not Available
- Gene Name:
- FMO2
- Uniprot ID:
- Q0P566
- Molecular weight:
- 47665.0
- General function:
- Involved in FAD binding
- Specific function:
- Not Available
- Gene Name:
- FMO3
- Uniprot ID:
- Q8HYK2
- Molecular weight:
- 2519.0
- General function:
- Lipid transport and metabolism
- Specific function:
- Active toward esters of long-chain and very long chain fatty acids such as palmitoyl-CoA, myristoyl-CoA and stearoyl-CoA. Can accommodate substrate acyl chain lengths as long as 24 carbons, but shows little activity for substrates of less than 12 carbons.
- Gene Name:
- ACADVL
- Uniprot ID:
- P48818
- Molecular weight:
- 70649.0
- General function:
- Lipid transport and metabolism
- Specific function:
- Acyl-CoA dehydrogenase specific for acyl chain lengths of 4 to 16 that catalyzes the initial step of fatty acid beta-oxidation. Utilizes the electron transfer flavoprotein (ETF) as an electron acceptor to transfer electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).
- Gene Name:
- ACADM
- Uniprot ID:
- Q3SZB4
- Molecular weight:
- 46573.0
- General function:
- Nucleotide transport and metabolism
- Specific function:
- Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
- Gene Name:
- NDUFA10
- Uniprot ID:
- P34942
- Molecular weight:
- 39264.0
- General function:
- Amino acid transport and metabolism
- Specific function:
- Dehydrogenase that converts trans-4-L-hydroxyproline to delta-1-pyrroline-3-hydroxy-5-carboxylate (Hyp) using ubiquinone-10 as the terminal electron acceptor. Can also use proline as a substrate but with a very much lower efficiency. Does not react with other diastereomers of Hyp: trans-4-D-hydroxyproline and cis-4-L-hydroxyproline. Ubiquininone analogs such as menadione, duroquinone and ubiquinone-1 react more efficiently than oxygen as the terminal electron acceptor during catalysis.
- Gene Name:
- PRODH2
- Uniprot ID:
- A6QQ74
- Molecular weight:
- 51262.0
- General function:
- Involved in electron carrier activity
- Specific function:
- Not Available
- Gene Name:
- Not Available
- Uniprot ID:
- Q6V1P7
- Molecular weight:
- 59904.0
- General function:
- Energy production and conversion
- Specific function:
- Not Available
- Gene Name:
- LDHD
- Uniprot ID:
- Q148K4
- Molecular weight:
- 54955.0
- General function:
- Translation, ribosomal structure and biogenesis
- Specific function:
- Not Available
- Gene Name:
- DUS1L
- Uniprot ID:
- A0JNQ2
- Molecular weight:
- 29871.0
- General function:
- Coenzyme transport and metabolism
- Specific function:
- FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.
- Gene Name:
- COQ6
- Uniprot ID:
- Q2KIL4
- Molecular weight:
- 51072.0
- General function:
- Amino acid transport and metabolism
- Specific function:
- Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
- Gene Name:
- FDXR
- Uniprot ID:
- P08165
- Molecular weight:
- 54338.0
- General function:
- Energy production and conversion
- Specific function:
- Not Available
- Gene Name:
- SDHA
- Uniprot ID:
- A7E3V1
- Molecular weight:
- 72933.0
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- Not Available
- Gene Name:
- FMO3
- Uniprot ID:
- Q8HYK1
- Molecular weight:
- 11349.0
- General function:
- Cell wall/membrane/envelope biogenesis
- Specific function:
- Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
- Gene Name:
- NDUFA9
- Uniprot ID:
- P34943
- Molecular weight:
- 42849.0
- General function:
- Involved in FAD binding
- Specific function:
- Not Available
- Gene Name:
- FMO3
- Uniprot ID:
- Q8HYK4
- Molecular weight:
- 5588.0
- General function:
- Energy production and conversion
- Specific function:
- Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate.
- Gene Name:
- GULO
- Uniprot ID:
- Q3ZC33
- Molecular weight:
- 50282.0
- General function:
- Amino acid transport and metabolism
- Specific function:
- Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). Involved in mid-late stages of complex I assembly.
- Gene Name:
- FOXRED1
- Uniprot ID:
- Q5EA45
- Molecular weight:
- 54082.0
- General function:
- Amino acid transport and metabolism
- Specific function:
- Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity).
- Gene Name:
- MAOB
- Uniprot ID:
- P56560
- Molecular weight:
- 58421.0
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Not Available
- Gene Name:
- OXNAD1
- Uniprot ID:
- Q58DM7
- Molecular weight:
- 34597.0
- General function:
- Lipid transport and metabolism
- Specific function:
- Not Available
- Gene Name:
- ACAD9
- Uniprot ID:
- A5D974
- Molecular weight:
- 68208.0
- General function:
- Lipid transport and metabolism
- Specific function:
- Has greatest activity toward short branched chain acyl-CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl-CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent (By similarity).
- Gene Name:
- ACADSB
- Uniprot ID:
- Q5EAD4
- Molecular weight:
- 47123.0
- General function:
- Energy production and conversion
- Specific function:
- A NAD(P)H-dependent oxidoreductase involved in cellular oxidative stress response. At the plasma membrane, catalyzes reduction of coenzyme Q/ubiquinone-10 to ubiquinol-10, a lipophilic radical-trapping antioxidant that prevents lipid oxidative damage and consequently ferroptosis. Cooperates with GPX4 to suppress phospholipid peroxidation and ferroptosis. This anti-ferroptotic function is independent of cellular glutathione levels. May play a role in mitochondrial stress signaling. Upon oxidative stress, associates with the lipid peroxidation end product 4-hydroxy-2-nonenal (HNE) forming a lipid adduct devoid of oxidoreductase activity, which then translocates from mitochondria into the nucleus triggering DNA damage and cell death. Capable of DNA binding in a non-sequence specific way.
- Gene Name:
- AIFM2
- Uniprot ID:
- A5PJM4
- Molecular weight:
- 40477.0
- General function:
- Amino acid transport and metabolism
- Specific function:
- Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
- Gene Name:
- MAOA
- Uniprot ID:
- P21398
- Molecular weight:
- 59758.0
- General function:
- Involved in FAD binding
- Specific function:
- Not Available
- Gene Name:
- FMO3
- Uniprot ID:
- Q8HYK3
- Molecular weight:
- 6318.0
- General function:
- Lipid transport and metabolism
- Specific function:
- Not Available
- Gene Name:
- ACAD11
- Uniprot ID:
- Q0P5G8
- Molecular weight:
- 87728.0
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.
- Gene Name:
- POR
- Uniprot ID:
- Q3SYT8
- Molecular weight:
- 77021.0
- General function:
- Lipid transport and metabolism
- Specific function:
- Isobutyryl-CoA dehydrogenase which catalyzes one of the steps of the valine catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA.
- Gene Name:
- ACAD8
- Uniprot ID:
- Q0NXR6
- Molecular weight:
- 45307.0
Only showing the first 50 proteins. There are 84 proteins in total.