Showing metabocard for Adenosine triphosphate (BMDB0000538)
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| Version | 1.0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Creation Date | 2016-09-30 22:32:23 UTC | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Update Date | 2020-06-04 20:34:03 UTC | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| BMDB ID | BMDB0000538 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Secondary Accession Numbers |
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| Metabolite Identification | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Common Name | Adenosine triphosphate | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Description | Adenosine triphosphate, also known as ATP or atriphos, belongs to the class of organic compounds known as purine ribonucleoside triphosphates. These are purine ribobucleotides with a triphosphate group linked to the ribose moiety. Adenosine triphosphate is a drug which is used for nutritional supplementation, also for treating dietary shortage or imbalance. Adenosine triphosphate is possibly soluble (in water) and a strong basic compound (based on its pKa). Adenosine triphosphate exists in all living species, ranging from bacteria to humans. Adenosine triphosphate is a potentially toxic compound. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Structure |  | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Synonyms |
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| Chemical Formula | C10H16N5O13P3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Average Molecular Weight | 507.181 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Monoisotopic Molecular Weight | 506.995745159 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| IUPAC Name | ({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Traditional Name | adenosine triphosphate | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CAS Registry Number | 56-65-5 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| SMILES | NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InChI Identifier | InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| InChI Key | ZKHQWZAMYRWXGA-KQYNXXCUSA-N | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Chemical Taxonomy | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Description | belongs to the class of organic compounds known as purine ribonucleoside triphosphates. These are purine ribobucleotides with a triphosphate group linked to the ribose moiety. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Kingdom | Organic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Super Class | Nucleosides, nucleotides, and analogues | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Class | Purine nucleotides | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Sub Class | Purine ribonucleotides | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Direct Parent | Purine ribonucleoside triphosphates | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Alternative Parents |
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| Substituents |
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| Molecular Framework | Aromatic heteropolycyclic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| External Descriptors |
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| Ontology | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Status | Detected and Quantified | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Origin |
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| Biofunction | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Application | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cellular locations |
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| Physical Properties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| State | Solid | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Experimental Properties |
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| Predicted Properties |
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| Spectra | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Spectra | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Biological Properties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Cellular Locations |
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| Biospecimen Locations |
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| Pathways |
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| Normal Concentrations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Abnormal Concentrations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Not Available | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| External Links | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| HMDB ID | HMDB0000538 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| DrugBank ID | DB00171 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Phenol Explorer Compound ID | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| FooDB ID | FDB030683 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| KNApSAcK ID | C00001491 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Chemspider ID | 5742 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| KEGG Compound ID | C00002 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| BioCyc ID | ATP | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| BiGG ID | 33477 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikipedia Link | Adenosine_triphosphate | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| METLIN ID | 5523 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PubChem Compound | 5957 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| PDB ID | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ChEBI ID | 15422 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Synthesis Reference | Clark, V. M.; Kirby, G. W.; Todd, Alexander. Phosphorylation. XV. Use of phosphoramidic esters in acylation-new preparation of adenosine 5'-pyrophosphate and adenosine 5'-triphosphate. Journal of the Chemical Society (1957), 1497-1501. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Material Safety Data Sheet (MSDS) | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| General References |
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Only showing the first 50 proteins. There are 103 proteins in total.
Enzymes
- General function:
- Translation, ribosomal structure and biogenesis
- Specific function:
- Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
- Gene Name:
- SARS2
- Uniprot ID:
- Q9N0F3
- Molecular weight:
- 58296.0
Reactions
| L-Serine + Adenosine triphosphate + L-Seryl-tRNA → Adenosine monophosphate + L-Seryl-tRNA(Ser) + Pyrophosphate | details |
- General function:
- Translation, ribosomal structure and biogenesis
- Specific function:
- Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.
- Gene Name:
- SARS1
- Uniprot ID:
- Q9GMB8
- Molecular weight:
- 58605.0
Reactions
| L-Serine + Adenosine triphosphate + L-Seryl-tRNA → Adenosine monophosphate + L-Seryl-tRNA(Ser) + Pyrophosphate | details |
- General function:
- Involved in ATP binding
- Specific function:
- Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (By similarity). Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (By similarity).
- Gene Name:
- ITPK1
- Uniprot ID:
- P0C0T1
- Molecular weight:
- 45842.0
Reactions
| Inositol 1,3,4,5,6-pentakisphosphate + ADP → D-Myo-inositol 3,4,5,6-tetrakisphosphate + Adenosine triphosphate | details |
| Adenosine triphosphate + Inositol 1,3,4-trisphosphate → ADP + 1D-Myo-inositol 1,3,4,6-tetrakisphosphate | details |
| Inositol 1,3,4-trisphosphate + Adenosine triphosphate → Inositol 1,3,4,5-tetraphosphate + ADP | details |
- General function:
- Lipid transport and metabolism
- Specific function:
- Performs the first committed step in the biosynthesis of isoprenes.
- Gene Name:
- MVD
- Uniprot ID:
- Q0P570
- Molecular weight:
- 43732.0
Reactions
| Adenosine triphosphate + 5-Diphosphomevalonic acid → ADP + Hydrogen phosphate + Isopentenyl pyrophosphate + Carbon dioxide | details |
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor (By similarity). Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+) (By similarity). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons (By similarity).
- Gene Name:
- NMNAT2
- Uniprot ID:
- Q0VC59
- Molecular weight:
- 34468.0
Reactions
| NAD + Pyrophosphate → Nicotinamide ribotide + Adenosine triphosphate | details |
| Nicotinic acid mononucleotide + Adenosine triphosphate → Nicotinic acid adenine dinucleotide + Pyrophosphate | details |
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.
- Gene Name:
- FPGS
- Uniprot ID:
- A6H751
- Molecular weight:
- 64900.0
Reactions
| Tetrahydrofolic acid + L-Glutamic acid + Adenosine triphosphate → Tetrahydrofolyl-[Glu](2) + ADP + Hydrogen phosphate | details |
| Tetrahydrofolyl-[Glu](2) + Adenosine triphosphate + L-Glutamic acid → Tetrahydrofolyl-[Glu](n) + ADP + Hydrogen phosphate | details |
- General function:
- Energy production and conversion
- Specific function:
- Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.
- Gene Name:
- ACLY
- Uniprot ID:
- Q32PF2
- Molecular weight:
- 119789.0
Reactions
| Coenzyme A + Citric acid + Adenosine triphosphate → Oxalacetic acid + ADP + Acetyl-CoA | details |
- General function:
- Involved in ATP binding
- Specific function:
- Not Available
- Gene Name:
- GSS
- Uniprot ID:
- Q5EAC2
- Molecular weight:
- 52066.0
Reactions
| Adenosine triphosphate + Gamma-Glutamylcysteine + Glycine → ADP + Hydrogen phosphate + Glutathione | details |
| Gamma-Glutamylcysteine + Adenosine triphosphate + Glycine → Glutathione + ADP + Hydrogen phosphate | details |
- General function:
- Lipid transport and metabolism
- Specific function:
- Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA.
- Gene Name:
- ACACA
- Uniprot ID:
- Q9TTS3
- Molecular weight:
- 265303.0
Reactions
| Adenosine triphosphate + Hydrogen carbonate + Acetyl-CoA → Hydrogen phosphate + ADP + Malonyl-CoA | details |
- General function:
- Nucleotide transport and metabolism
- Specific function:
- One of the enzymes of the urea cycle, the metabolic pathway transforming neurotoxic amonia produced by protein catabolism into inocuous urea in the liver of ureotelic animals. Catalyzes the formation of arginosuccinate from aspartate, citrulline and ATP and together with ASL it is responsible for the biosynthesis of arginine in most body tissues.
- Gene Name:
- ASS1
- Uniprot ID:
- P14568
- Molecular weight:
- 46417.0
Reactions
| Adenosine triphosphate + Citrulline + L-Aspartic acid → Adenosine monophosphate + Pyrophosphate + Argininosuccinic acid | details |
- General function:
- Involved in ATP binding
- Specific function:
- This is one of the 2 subunits of the biotin-dependent propionyl-CoA carboxylase (PCC), a mitochondrial enzyme involved in the catabolism of odd chain fatty acids, branched-chain amino acids isoleucine, threonine, methionine, and valine and other metabolites. Propionyl-CoA carboxylase catalyzes the carboxylation of propionyl-CoA/propanoyl-CoA to D-methylmalonyl-CoA/(S)-methylmalonyl-CoA (By similarity). Within the holoenzyme, the alpha subunit catalyzes the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain, while the beta subunit then transfers the carboxyl group from carboxylated biotin to propionyl-CoA (By similarity). Propionyl-CoA carboxylase also significantly acts on butyryl-CoA/butanoyl-CoA, which is converted to ethylmalonyl-CoA/(2S)-ethylmalonyl-CoA (By similarity). Other alternative minor substrates include (2E)-butenoyl-CoA/crotonoyl-CoA (By similarity).
- Gene Name:
- PCCB
- Uniprot ID:
- Q2TBR0
- Molecular weight:
- 58311.0
Reactions
| 3-Methylcrotonyl-CoA + Adenosine triphosphate + Hydrogen carbonate → 3-Methylglutaconyl-CoA + ADP | details |
| Propionyl-CoA + Adenosine triphosphate + Hydrogen carbonate → S-Methylmalonyl-CoA + ADP + Hydrogen phosphate | details |
| Propionyl-CoA + Hydrogen carbonate + Adenosine triphosphate → S-Methylmalonyl-CoA + ADP + Hydrogen | details |
- General function:
- Involved in ATP binding
- Specific function:
- Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (By similarity).
- Gene Name:
- CKB
- Uniprot ID:
- Q5EA61
- Molecular weight:
- 42719.0
Reactions
| Adenosine triphosphate + Creatine → ADP + Phosphocreatine | details |
- General function:
- Lipid transport and metabolism
- Specific function:
- Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids (By similarity). Propionate is the preferred substrate but can also utilize acetate and butyrate with a much lower affinity.
- Gene Name:
- ACSS3
- Uniprot ID:
- A7MB45
- Molecular weight:
- 74805.0
Reactions
| Propinol adenylate + Adenosine triphosphate + Pantetheine → Propionyl-CoA + Adenosine monophosphate + Pyrophosphate | details |
| Caproic acid + Adenosine triphosphate + Coenzyme A → Hexanoyl-CoA + Adenosine monophosphate + Pyrophosphate | details |
- General function:
- Translation, ribosomal structure and biogenesis
- Specific function:
- Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged tRNA(Thr) via its editing domain, at the post-transfer stage.
- Gene Name:
- TARS1
- Uniprot ID:
- Q3ZBV8
- Molecular weight:
- 83492.0
Reactions
| Adenosine triphosphate + L-Threonine + tRNA(Thr) → Adenosine monophosphate + Pyrophosphate + L-Threonyl-tRNA(Thr) | details |
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
- Gene Name:
- MAT1A
- Uniprot ID:
- Q2KJC6
- Molecular weight:
- 43761.0
Reactions
| Selenomethionine + Adenosine triphosphate + Water → Se-Adenosylselenomethionine + Hydrogen phosphate + Pyrophosphate | details |
| Adenosine triphosphate + L-Methionine + Water → S-Adenosylmethionine + Hydrogen phosphate + Pyrophosphate | details |
- General function:
- Signal transduction mechanisms
- Specific function:
- Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:2472670, PubMed:2022671. PubMed:19029295). Mediates responses to increased cellular Ca(2+)/calmodulin levels (PubMed:2022671, PubMed:19029295). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina (By similarity).
- Gene Name:
- ADCY1
- Uniprot ID:
- P19754
- Molecular weight:
- 123979.0
Reactions
| Adenosine triphosphate → Cyclic AMP + Pyrophosphate | details |
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (By similarity). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity).
- Gene Name:
- PFKL
- Uniprot ID:
- A1A4J1
- Molecular weight:
- 85292.0
Reactions
| Fructose 6-phosphate + Adenosine triphosphate → Fructose 1,6-bisphosphate + ADP | details |
- General function:
- Nucleotide transport and metabolism
- Specific function:
- Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.
- Gene Name:
- PRPS1
- Uniprot ID:
- Q2HJ58
- Molecular weight:
- 34834.0
Reactions
| D-Ribose 5-phosphate + Adenosine triphosphate → Phosphoribosyl pyrophosphate + Adenosine monophosphate | details |
- General function:
- Nucleotide transport and metabolism
- Specific function:
- Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity).
- Gene Name:
- NME7
- Uniprot ID:
- Q5E9Y9
- Molecular weight:
- 42599.0
Reactions
| Adenosine triphosphate + Guanosine diphosphate → ADP + Guanosine triphosphate | details |
| Adenosine triphosphate + dGDP → ADP + dGTP | details |
| Adenosine triphosphate + IDP → ADP + Inosine triphosphate | details |
| Uridine triphosphate + ADP → Uridine 5'-diphosphate + Adenosine triphosphate | details |
| Cytidine triphosphate + ADP → CDP + Adenosine triphosphate | details |
| dCDP + Adenosine triphosphate → dCTP + ADP | details |
| dTDP + Adenosine triphosphate → Thymidine 5'-triphosphate + ADP | details |
| Deoxyuridine triphosphate + ADP → dUDP + Adenosine triphosphate | details |
- General function:
- Nucleotide transport and metabolism
- Specific function:
- Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically. Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (By similarity). Exhibits histidine protein kinase activity (PubMed:12486123).
- Gene Name:
- NME2
- Uniprot ID:
- Q3T0Q4
- Molecular weight:
- 17316.0
Reactions
| Adenosine triphosphate + Uridine 5'-diphosphate → ADP + Uridine triphosphate | details |
- General function:
- Lipid transport and metabolism
- Specific function:
- Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:11382754, PubMed:10561077). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:10561077, PubMed:11382754). Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (PubMed:11382754). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (PubMed:11382754).
- Gene Name:
- ACSM1
- Uniprot ID:
- Q9BEA2
- Molecular weight:
- 64923.0
Reactions
| Dodecanoic acid + Adenosine triphosphate + Coenzyme A → Lauroyl-CoA + Adenosine monophosphate + Pyrophosphate | details |
- General function:
- Nucleotide transport and metabolism
- Specific function:
- Contributes to the de novo mitochondrial thymidylate biosynthesis pathway.
- Gene Name:
- TYMS
- Uniprot ID:
- Q2TA32
- Molecular weight:
- 39785.0
Reactions
| 5-Thymidylic acid + Adenosine triphosphate → dTDP + ADP | details |
| dUMP + Adenosine triphosphate → dUDP + ADP | details |
- General function:
- Translation, ribosomal structure and biogenesis
- Specific function:
- Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
- Gene Name:
- DARS1
- Uniprot ID:
- Q3SYZ4
- Molecular weight:
- 57036.0
Reactions
| Adenosine triphosphate + L-Aspartic acid + tRNA(Asp) → Adenosine monophosphate + Pyrophosphate + L-Aspartyl-tRNA(Asp) | details |
- General function:
- Nucleotide transport and metabolism
- Specific function:
- Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor (By similarity).
- Gene Name:
- UCK1
- Uniprot ID:
- Q0P5A4
- Molecular weight:
- 31195.0
Reactions
| Deoxycytidine + Adenosine triphosphate → dCMP + ADP | details |
| Uridine + Adenosine triphosphate → Uridine 5'-monophosphate + ADP | details |
- General function:
- Amino acid transport and metabolism
- Specific function:
- Synthesizes selenophosphate from selenide and ATP.
- Gene Name:
- SEPHS1
- Uniprot ID:
- Q0VC82
- Molecular weight:
- 42881.0
Reactions
| Adenosine triphosphate + Hydrogen selenide + Water → Adenosine monophosphate + Phosphoroselenoic acid + Hydrogen phosphate | details |
- General function:
- Involved in ATP binding
- Specific function:
- Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate (By similarity).
- Gene Name:
- PC
- Uniprot ID:
- Q29RK2
- Molecular weight:
- 129698.0
Reactions
| Adenosine triphosphate + Pyruvic acid + Hydrogen carbonate → ADP + Hydrogen phosphate + Oxalacetic acid | details |
| 3-Methylcrotonyl-CoA + Adenosine triphosphate + Hydrogen carbonate → 3-Methylglutaconyl-CoA + ADP | details |
| Propionyl-CoA + Adenosine triphosphate + Hydrogen carbonate → S-Methylmalonyl-CoA + ADP + Hydrogen phosphate | details |
| Propionyl-CoA + Hydrogen carbonate + Adenosine triphosphate → S-Methylmalonyl-CoA + ADP + Hydrogen | details |
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- Converts endogenous N-acetylglucosamine (GlcNAc), a major component of complex carbohydrates, from lysosomal degradation or nutritional sources into GlcNAc 6-phosphate. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway. Also has ManNAc kinase activity (By similarity).
- Gene Name:
- NAGK
- Uniprot ID:
- Q3SZM9
- Molecular weight:
- 37268.0
Reactions
| 3 N-Acetyl-D-Glucosamine 6-Phosphate + 3 Adenosine diphosphate ribose →3 Chitin +3 Adenosine triphosphate | details |
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
- Gene Name:
- NADSYN1
- Uniprot ID:
- Q3ZBF0
- Molecular weight:
- 79400.0
Reactions
| Nicotinic acid adenine dinucleotide + Adenosine triphosphate + Water + L-Glutamine → NAD + Adenosine monophosphate + Pyrophosphate + L-Glutamic acid | details |
- General function:
- Translation, ribosomal structure and biogenesis
- Specific function:
- Glutamine--tRNA ligase. Plays a critical role in brain development.
- Gene Name:
- QARS1
- Uniprot ID:
- Q3MHH4
- Molecular weight:
- 87643.0
Reactions
| L-Glutamine + Adenosine triphosphate + tRNA(Gln) → Adenosine monophosphate + Pyrophosphate + L-Glutaminyl-tRNA(Gln) | details |
- General function:
- Amino acid transport and metabolism
- Specific function:
- Catalyzes the cleavage of 5-oxo-L-proline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
- Gene Name:
- OPLAH
- Uniprot ID:
- Q75WB5
- Molecular weight:
- 137450.0
Reactions
| Adenosine triphosphate + Pyroglutamic acid + 2 Water → ADP + Hydrogen phosphate + L-Glutamic acid | details |
- General function:
- Nucleotide transport and metabolism
- Specific function:
- Phosphorylates the deoxyribonucleosides deoxycytidine, deoxyguanosine and deoxyadenosine.
- Gene Name:
- DCK
- Uniprot ID:
- Q3MHR2
- Molecular weight:
- 30329.0
Reactions
| Adenosine triphosphate + Deoxyguanosine → ADP + 2'-Deoxyguanosine 5'-monophosphate | details |
- General function:
- Involved in ATP binding
- Specific function:
- Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively). Does not phosphorylate N-acetyl-D-glucosamine (By similarity). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan. When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (By similarity).
- Gene Name:
- HK1
- Uniprot ID:
- P27595
- Molecular weight:
- 103064.0
Reactions
| D-Fructose + Adenosine triphosphate → Fructose 6-phosphate + ADP | details |
| Glucosamine + Adenosine triphosphate → Glucosamine 6-phosphate + ADP | details |
| D-Mannose + Adenosine triphosphate → Mannose 6-phosphate + ADP | details |
| Adenosine triphosphate + Alpha-D-Glucose → ADP + Glucose 6-phosphate | details |
| D-Glucose + Adenosine triphosphate → Glucose 6-phosphate + ADP | details |
| Alpha-D-Glucose + Adenosine triphosphate → Glucose 6-phosphate + ADP | details |
| Adenosine triphosphate + Beta-D-Glucose → ADP + Beta-D-Glucose 6-phosphate | details |
| Adenosine triphosphate + D-Fructose → ADP + Beta-D-Fructose 6-phosphate | details |
| Beta-D-Glucose + Adenosine triphosphate → Beta-D-Glucose 6-phosphate + ADP | details |
- General function:
- Translation, ribosomal structure and biogenesis
- Specific function:
- T1-TrpRS has aminoacylation activity while T2-TrpRS lacks it. T1-TrpRS and T2-TrpRS possess angiostatic activity. T2-TrpRS inhibits fluid shear stress-activated responses of endothelial cells. Regulates ERK, Akt, and eNOS activation pathways that are associated with angiogenesis, cytoskeletal reorganization and shear stress-responsive gene expression (By similarity).
- Gene Name:
- WARS1
- Uniprot ID:
- P17248
- Molecular weight:
- 53812.0
Reactions
| Adenosine triphosphate + L-Tryptophan + tRNA(Trp) → Adenosine monophosphate + Pyrophosphate + L-Tryptophyl-tRNA(Trp) | details |
- General function:
- Translation, ribosomal structure and biogenesis
- Specific function:
- Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis.
- Gene Name:
- WARS2
- Uniprot ID:
- Q3T099
- Molecular weight:
- 40205.0
Reactions
| Adenosine triphosphate + L-Tryptophan + tRNA(Trp) → Adenosine monophosphate + Pyrophosphate + L-Tryptophyl-tRNA(Trp) | details |
- General function:
- Involved in calcium ion binding
- Specific function:
- Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity.
- Gene Name:
- DGKA
- Uniprot ID:
- A0JN54
- Molecular weight:
- 82672.0
Reactions
| DG(16:0/16:0/0:0) + Adenosine triphosphate → PA(16:0/16:0) + ADP | details |
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate (By similarity).
- Gene Name:
- TPK1
- Uniprot ID:
- Q5E9T4
- Molecular weight:
- 27028.0
Reactions
| Adenosine triphosphate + Thiamine → Adenosine monophosphate + Thiamine pyrophosphate | details |
| Adenosine triphosphate + Thiamine pyrophosphate → ADP + Thiamin triphosphate | details |
- General function:
- Lipid transport and metabolism
- Specific function:
- Catalyzes the conversion of fatty acids such as long-chain and very long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids.
- Gene Name:
- ACSBG1
- Uniprot ID:
- Q2KHW5
- Molecular weight:
- 80585.0
Reactions
| Palmitic acid + Adenosine triphosphate + Coenzyme A → Palmityl-CoA + Adenosine monophosphate + Pyrophosphate | details |
| Phytanic acid + Adenosine triphosphate + Coenzyme A → Phytanoyl-CoA + ADP + Pyrophosphate | details |
| Tetracosanoic acid + Adenosine triphosphate + Coenzyme A → Tetracosanoyl-CoA + ADP | details |
| Stearic acid + Coenzyme A + Adenosine triphosphate → Stearoyl-CoA + Pyrophosphate + Adenosine monophosphate | details |
- General function:
- Translation, ribosomal structure and biogenesis
- Specific function:
- Catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP). Plays a role in axon guidance.
- Gene Name:
- HARS1
- Uniprot ID:
- Q2KI84
- Molecular weight:
- 57285.0
Reactions
| Adenosine triphosphate + L-Histidine + tRNA(His) → Adenosine monophosphate + Pyrophosphate + L-Histidyl-tRNA(His) | details |
- General function:
- Translation, ribosomal structure and biogenesis
- Specific function:
- Mitochondrial aminoacyl-tRNA synthetase that catalyzes the ATP-dependent ligation of histidine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (His-AMP).
- Gene Name:
- HARS2
- Uniprot ID:
- A5D7V9
- Molecular weight:
- 56914.0
Reactions
| Adenosine triphosphate + L-Histidine + tRNA(His) → Adenosine monophosphate + Pyrophosphate + L-Histidyl-tRNA(His) | details |
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- Not Available
- Gene Name:
- GLYCTK
- Uniprot ID:
- Q2KJF7
- Molecular weight:
- 54720.0
Reactions
| 3-Phosphoglyceric acid + Adenosine triphosphate → Glyceric acid + ADP | details |
| Glyceric acid + Adenosine triphosphate → 3-Phosphoglyceric acid + ADP | details |
Only showing the first 50 proteins. There are 103 proteins in total.