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Showing metabocard for Water (BMDB0002111)
Record Information | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Version | 1.0 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Creation Date | 2016-09-30 22:51:19 UTC | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Update Date | 2020-06-04 23:01:07 UTC | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
BMDB ID | BMDB0002111 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Secondary Accession Numbers |
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Metabolite Identification | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Common Name | Water | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Description | Water, also known as dihydrogen oxide or [OH2], belongs to the class of inorganic compounds known as homogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other non-metals'. Water is a drug which is used for diluting or dissolving drugs for intravenous, intramuscular or subcutaneous injection, according to instructions of the manufacturer of the drug to be administered [fda label]. Water exists as a liquid, possibly soluble (in water), and an extremely weak basic (essentially neutral) compound (based on its pKa) molecule. Water exists in all living species, ranging from bacteria to humans. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Structure | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Synonyms |
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Chemical Formula | H2O | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Average Molecular Weight | 18.0153 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Monoisotopic Molecular Weight | 18.010564686 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
IUPAC Name | water | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Traditional Name | water | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
CAS Registry Number | 7732-18-5 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
SMILES | O | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
InChI Identifier | InChI=1S/H2O/h1H2 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
InChI Key | XLYOFNOQVPJJNP-UHFFFAOYSA-N | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Chemical Taxonomy | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Description | belongs to the class of inorganic compounds known as homogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other non-metals'. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Kingdom | Inorganic compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Super Class | Homogeneous non-metal compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Class | Homogeneous other non-metal compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sub Class | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Direct Parent | Homogeneous other non-metal compounds | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Alternative Parents | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Substituents |
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Molecular Framework | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
External Descriptors |
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Ontology | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Status | Detected and Quantified | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Origin |
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Biofunction | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Application | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cellular locations |
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Physical Properties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
State | Liquid | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Experimental Properties |
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Predicted Properties |
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Spectra | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Spectra | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Biological Properties | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Cellular Locations |
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Biospecimen Locations |
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Pathways | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Normal Concentrations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Abnormal Concentrations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Not Available | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
External Links | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
HMDB ID | HMDB0002111 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
DrugBank ID | DB09145 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Phenol Explorer Compound ID | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
FooDB ID | FDB030900 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
KNApSAcK ID | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Chemspider ID | 937 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
KEGG Compound ID | C00001 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
BioCyc ID | WATER | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
BiGG ID | 33474 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Wikipedia Link | Water | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
METLIN ID | 3194 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
PubChem Compound | 962 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
PDB ID | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
ChEBI ID | 15377 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
References | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Synthesis Reference | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Material Safety Data Sheet (MSDS) | Not Available | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
General References |
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Only showing the first 50 proteins. There are 161 proteins in total.
Enzymes
- General function:
- Secondary metabolites biosynthesis, transport and catabolism
- Specific function:
- A cytochrome P450 monooxygenase that catalyzes the conversion of C19 androgens, androst-4-ene-3,17-dione (androstenedione) and testosterone to the C18 estrogens, estrone and estradiol, respectively. Catalyzes three successive oxidations of C19 androgens: two conventional oxidations at C19 yielding 19-hydroxy and 19-oxo/19-aldehyde derivatives, followed by a third oxidative aromatization step that involves C1-beta hydrogen abstraction combined with cleavage of the C10-C19 bond to yield a phenolic A ring and formic acid. Alternatively, the third oxidative reaction yields a 19-norsteroid and formic acid. Converts dihydrotestosterone to delta1,10-dehydro 19-nordihydrotestosterone and may play a role in homeostasis of this potent androgen. Also displays 2-hydroxylase activity toward estrone. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
- Gene Name:
- CYP19A1
- Uniprot ID:
- P46194
- Molecular weight:
- 58090.0
Reactions
Androstenedione + Oxygen + Reduced flavoprotein → 19-Hydroxyandrost-4-ene-3,17-dione + Water + Oxidized flavoprotein | details |
- General function:
- Secondary metabolites biosynthesis, transport and catabolism
- Specific function:
- A cytochrome P450 monooxygenase involved in the biosynthesis of adrenal corticoids. Catalyzes the hydroxylation of carbon hydrogen bond at 11-beta position of 11-deoxycortisol and 11-deoxycorticosterone/21-hydroxyprogesterone yielding cortisol or corticosterone, respectively. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).
- Gene Name:
- CYP11B1
- Uniprot ID:
- P15150
- Molecular weight:
- 57847.0
Reactions
Deoxycorticosterone + Oxygen + Reduced adrenal ferredoxin → Corticosterone + Water + Oxidized adrenal ferredoxin | details |
Progesterone + Oxygen + Reduced adrenal ferredoxin → 11b-Hydroxyprogesterone + Water + Oxidized adrenal ferredoxin | details |
17-Hydroxyprogesterone + Oxygen + Reduced adrenal ferredoxin → 21-Deoxycortisol + Water + Oxidized adrenal ferredoxin | details |
Cortexolone + Oxygen + Reduced adrenal ferredoxin → Cortisol + Water + Oxidized adrenal ferredoxin | details |
17a,21-Dihydroxypreg-nenolone + Oxygen + Reduced adrenal ferredoxin → 11b,17a,21-Trihydroxypreg-nenolone + Water + Oxidized adrenal ferredoxin | details |
- General function:
- Secondary metabolites biosynthesis, transport and catabolism
- Specific function:
- A cytochrome P450 monooxygenase involved in sterol biosynthesis. Catalyzes 14-alpha demethylation of lanosterol and 24,25-dihydrolanosterol likely through sequential oxidative conversion of 14-alpha methyl group to hydroxymethyl, then to carboxylaldehyde, followed by the formation of the delta 14,15 double bond in the sterol core and concomitant release of formic acid. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
- Gene Name:
- CYP51A1
- Uniprot ID:
- Q4PJW3
- Molecular weight:
- 56596.0
Reactions
Lanosterin + 3 Oxygen + 3 NADPH → 4,4-Dimethylcholesta-8,14,24-trienol + Formic acid +3 NADP +4 Water | details |
24-Hydroxycholesterol + NADPH + Oxygen → (24R)-Cholest-5-ene-3-beta,7-alpha,24-triol + NADP + Water | details |
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells.
- Gene Name:
- CAT
- Uniprot ID:
- P00432
- Molecular weight:
- 59915.0
Reactions
2 Hydrogen peroxide → Oxygen +2 Water | details |
Ethanol + Hydrogen peroxide → Acetaldehyde +2 Water | details |
2 3-Hydroxyanthranilic acid + Oxygen → Cinnavalininate +2 Water | details |
- General function:
- Secondary metabolites biosynthesis, transport and catabolism
- Specific function:
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
- Gene Name:
- CYP3A28
- Uniprot ID:
- P79102
- Molecular weight:
- 58152.0
Reactions
6-trans-Leukotriene B4 + NADPH + Oxygen → 20-Hydroxy-leukotriene B4 + NADP + Water | details |
Arachidonic acid + NADPH + Oxygen → 20-Hydroxyeicosatetraenoic acid + NADP + Water | details |
Cholesterol + NADPH + Oxygen → 24-Hydroxycholesterol + NADP + Water | details |
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
- Gene Name:
- NOS3
- Uniprot ID:
- P29473
- Molecular weight:
- 133287.0
Reactions
2 L-Arginine + 3 NADPH + 4 Oxygen →2 N-(o)-Hydroxyarginine +2 Nitric oxide +3 NADP +4 Water | details |
- General function:
- Secondary metabolites biosynthesis, transport and catabolism
- Specific function:
- Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2).
- Gene Name:
- PTGIS
- Uniprot ID:
- Q29626
- Molecular weight:
- 56629.0
Reactions
7a-Hydroxy-cholestene-3-one + NADPH + Oxygen → 7a,12a-Dihydroxy-cholestene-3-one + NADP + Water | details |
Cholesterol + 3 NADPH + 3 Oxygen → 27-Hydroxycholesterol +3 NADP +4 Water | details |
27-Hydroxycholesterol + NADPH + Oxygen → 7-a,27-dihydroxycholesterol + NADP + Water | details |
3beta-Hydroxy-5-cholestenoic acid + NADPH + Oxygen → 3 beta,7 alpha-Dihydroxy-5-cholestenoate + NADP + Water | details |
- General function:
- Secondary metabolites biosynthesis, transport and catabolism
- Specific function:
- A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
- Gene Name:
- CYP17A1
- Uniprot ID:
- P05185
- Molecular weight:
- 57244.0
Reactions
21-Deoxycortisol + Water + Acceptor → 11b-Hydroxyprogesterone + Oxygen + Reduced acceptor | details |
Progesterone + Oxygen + Reduced acceptor → 17-Hydroxyprogesterone + Water + Acceptor | details |
- General function:
- Secondary metabolites biosynthesis, transport and catabolism
- Specific function:
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
- Gene Name:
- CYP2D14
- Uniprot ID:
- Q01361
- Molecular weight:
- 56083.0
Reactions
Arachidonic acid + Oxygen → 19(S)-HETE + Water | details |
- General function:
- Secondary metabolites biosynthesis, transport and catabolism
- Specific function:
- A cytochrome P450 monooxygenase involved in the metabolism of arachidonic acid and its conjugates. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Acts as an omega and omega-1 hydroxylase for arachidonic acid and possibly for other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. May downregulate the biological activities of N-arachidonoyl-serotonin, an endocannabinoid that has anti-nociceptive effects through inhibition of fatty acid amide hydrolase FAAH, TRPV1 receptor and T-type calcium channels. Catalyzes C-2 oxidation of the indole ring of N-arachidonoyl-serotonin forming a less active product 2-oxo-N-arachidonoyl-serotonin.
- Gene Name:
- CYP2U1
- Uniprot ID:
- Q0IIF9
- Molecular weight:
- 61997.0
Reactions
Melatonin + Oxygen + Reduced flavoprotein → 6-Hydroxymelatonin + Water + Oxidized flavoprotein | details |
Arachidonic acid + Oxygen → 19(S)-HETE + Water | details |
- General function:
- Secondary metabolites biosynthesis, transport and catabolism
- Specific function:
- A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones (PubMed:11412116). Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal (PubMed:11412116). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed:11412116).
- Gene Name:
- CYP11A1
- Uniprot ID:
- P00189
- Molecular weight:
- 60333.0
Reactions
3a,7a-Dihydroxy-5b-cholestane + 3 NADPH + 3 Oxygen → 3 alpha,7 alpha,26-Trihydroxy-5beta-cholestane +3 NADP +3 Water | details |
5-b-Cholestane-3a ,7a ,12a-triol + 3 NADPH + 3 Oxygen → 27-Deoxy-5b-cyprinol +3 NADP +4 Water | details |
27-Deoxy-5b-cyprinol + 3 NADPH + 3 Oxygen → 3a,7a,12a-Trihydroxy-5b-cholestan-26-al +3 NADP +4 Water | details |
27-Hydroxycholesterol + 3 NADPH + 3 Oxygen → 3beta-Hydroxy-5-cholestenoic acid +3 NADP +4 Water | details |
- General function:
- Secondary metabolites biosynthesis, transport and catabolism
- Specific function:
- Specifically catalyzes the 21-hydroxylation of steroids. Required for the adrenal synthesis of mineralocorticoids and glucocorticoids.
- Gene Name:
- CYP21
- Uniprot ID:
- P00191
- Molecular weight:
- 56077.0
Reactions
11b-Hydroxyprogesterone + Oxygen + Reduced acceptor → Corticosterone + Water + Acceptor | details |
21-Deoxycortisol + Oxygen + Reduced acceptor → Cortisol + Water + Acceptor | details |
Progesterone + Oxygen + Reduced acceptor → Deoxycorticosterone + Water + Acceptor | details |
17-Hydroxyprogesterone + Oxygen + Reduced acceptor → Cortexolone + Water + Acceptor | details |
- General function:
- Secondary metabolites biosynthesis, transport and catabolism
- Specific function:
- A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.
- Gene Name:
- CYP2E1
- Uniprot ID:
- O18963
- Molecular weight:
- 56827.0
Reactions
Arachidonic acid + Oxygen → 14,15-epoxy-5,8,11-eicosatrienoic acid + Water | details |
Arachidonic acid + Oxygen → 11,12-Epoxyeicosatrienoic acid + Water | details |
Arachidonic acid + Oxygen → 8,9-Epoxyeicosatrienoic acid + Water | details |
Arachidonic acid + Oxygen → 5,6-Epoxy-8,11,14-eicosatrienoic acid + Water | details |
- General function:
- Cell cycle control, cell division, chromosome partitioning
- Specific function:
- The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
- Gene Name:
- PLCB1
- Uniprot ID:
- P10894
- Molecular weight:
- 138715.0
Reactions
PIP2 + Water → DG + IP3 | details |
phosphatidylinositol 4,5-bisphosphate + Water → 1,2-Diacyl-sn-glycerol + Inositol 1,4,5-trisphosphate | details |
- General function:
- Involved in calcium ion binding
- Specific function:
- Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration (By similarity).
- Gene Name:
- PLCG1
- Uniprot ID:
- P08487
- Molecular weight:
- 148313.0
Reactions
PIP2 + Water → DG + IP3 | details |
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- Hydrolyzes cerebroside sulfate.
- Gene Name:
- ARSA
- Uniprot ID:
- Q08DD1
- Molecular weight:
- 53807.0
Reactions
3-O-Sulfogalactosylceramide (d18:1/24:0) + Water → Galactosylceramide (d18:1/16:0) + Sulfate | details |
DHEA sulfate + Water → Dehydroepiandrosterone + Sulfate | details |
- General function:
- Amino acid transport and metabolism
- Specific function:
- Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis. Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA. Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs. Associates with mitochondrial DNA. In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex.
- Gene Name:
- SHMT2
- Uniprot ID:
- Q3SZ20
- Molecular weight:
- 55605.0
Reactions
5,10-Methylene-THF + Glycine + Water → Tetrahydrofolic acid + L-Serine | details |
- General function:
- Amino acid transport and metabolism
- Specific function:
- Interconversion of serine and glycine.
- Gene Name:
- SHMT1
- Uniprot ID:
- Q5E9P9
- Molecular weight:
- 52978.0
Reactions
L-Serine + Tetrahydrofolic acid → Glycine + 5,10-Methylene-THF + Water | details |
Tetrahydrofolic acid + L-Serine → 5,10-Methylene-THF + Glycine + Water | details |
- General function:
- Secondary metabolites biosynthesis, transport and catabolism
- Specific function:
- Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity (By similarity).
- Gene Name:
- AOC3
- Uniprot ID:
- Q9TTK6
- Molecular weight:
- 84500.0
Reactions
1,3-Diaminopropane + Oxygen + Water → 3-Aminopropionaldehyde + Ammonia + Hydrogen peroxide | details |
Histamine + Water + Oxygen → Imidazole-4-acetaldehyde + Ammonia + Hydrogen peroxide | details |
Tyramine + Water + Oxygen → Homovanillin + Hydrogen peroxide + Ammonia | details |
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.
- Gene Name:
- HMBS
- Uniprot ID:
- Q2KIN5
- Molecular weight:
- 39515.0
Reactions
4 Porphobilinogen + Water → Hydroxymethylbilane +4 Ammonia | details |
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
- Gene Name:
- ALAD
- Uniprot ID:
- Q58DK5
- Molecular weight:
- 36081.0
Reactions
5-Aminolevulinic acid → Porphobilinogen +2 Water | details |
- General function:
- Involved in 5'-nucleotidase activity
- Specific function:
- May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.
- Gene Name:
- NT5C2
- Uniprot ID:
- O46411
- Molecular weight:
- 64841.0
Reactions
2'-Deoxyguanosine 5'-monophosphate + Water → Deoxyguanosine + Hydrogen phosphate | details |
Guanosine monophosphate + Water → Guanosine + Hydrogen phosphate | details |
Xanthylic acid + Water → Xanthosine + Hydrogen phosphate | details |
Inosinic acid + Water → Inosine + Hydrogen phosphate | details |
Deoxyadenosine monophosphate + Water → Deoxyadenosine + Hydrogen phosphate | details |
Nicotinamide riboside + Hydrogen phosphate → Nicotinamide ribotide + Water | details |
Nicotinic acid mononucleotide + Water → Nicotinate D-ribonucleoside + Hydrogen phosphate | details |
Uridine 5'-monophosphate + Water → Uridine + Hydrogen phosphate | details |
dCMP + Water → Deoxycytidine + Hydrogen phosphate | details |
5-Thymidylic acid + Water → Thymidine + Hydrogen phosphate | details |
- General function:
- Not Available
- Specific function:
- Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside NTPDases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Has activity toward ATP, ADP, UTP and UDP, but not toward AMP (By similarity).
- Gene Name:
- ENTPD8
- Uniprot ID:
- A0JND9
- Molecular weight:
- 53240.0
Reactions
IDP + Water → Inosinic acid + Hydrogen phosphate | details |
Inosine triphosphate + Water → IDP + Hydrogen phosphate | details |
Guanosine triphosphate + Water → Guanosine diphosphate + Hydrogen phosphate | details |
- General function:
- Involved in glucose-6-phosphatase activity
- Specific function:
- Hydrolyzes glucose-6-phosphate to glucose in the endoplasmic reticulum. Forms with the glucose-6-phosphate transporter (SLC37A4/G6PT) the complex responsible for glucose production through glycogenolysis and gluconeogenesis. Hence, it is the key enzyme in homeostatic regulation of blood glucose levels (By similarity).
- Gene Name:
- G6PC
- Uniprot ID:
- Q29RU6
- Molecular weight:
- 40827.0
Reactions
Glucose 1-phosphate + Water → D-Glucose + Hydrogen phosphate | details |
Glucose 6-phosphate + Water → D-Glucose + Hydrogen phosphate | details |
Alpha-D-Glucose + Hydrogen phosphate → Glucose 6-phosphate + Water | details |
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate in the presence of divalent cations, acting as a rate-limiting enzyme in gluconeogenesis. Plays a role in regulating glucose sensing and insulin secretion of pancreatic beta-cells. Appears to modulate glycerol gluconeogenesis in liver. Important regulator of appetite and adiposity; increased expression of the protein in liver after nutrient excess increases circulating satiety hormones and reduces appetite-stimulating neuropeptides and thus seems to provide a feedback mechanism to limit weight gain.
- Gene Name:
- FBP1
- Uniprot ID:
- Q3SZB7
- Molecular weight:
- 36728.0
Reactions
Fructose 1,6-bisphosphate + Water → Fructose 6-phosphate + Hydrogen phosphate | details |
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. Has 1000-fold lower activity towards inositol 1,4-bisphosphate (Ins(1,4)P2) and inositol 1,3,4-trisphosphate (Ins(1,3,4)P3), but does not hydrolyze Ins(1)P, Ins(3,4)P2, Ins(1,3,4,5)P4 or InsP6 (By similarity).
- Gene Name:
- BPNT1
- Uniprot ID:
- Q3ZCK3
- Molecular weight:
- 33328.0
Reactions
Phosphoadenosine phosphosulfate + Water → Adenosine phosphosulfate + Hydrogen phosphate | details |
- General function:
- Nucleotide transport and metabolism
- Specific function:
- Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. Hydrolyzes nucleoside diphosphates with lower efficiency (By similarity).
- Gene Name:
- NTPCR
- Uniprot ID:
- Q1LZ78
- Molecular weight:
- 20682.0
Reactions
Thiamine pyrophosphate + Water → Thiamine monophosphate + Hydrogen phosphate | details |
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).
- Gene Name:
- PNPO
- Uniprot ID:
- Q5E9K3
- Molecular weight:
- 30366.0
Reactions
Pyridoxamine + Water + Oxygen → Pyridoxal + Ammonia + Hydrogen peroxide | details |
Pyridoxamine 5'-phosphate + Water + Oxygen → Pyridoxal 5'-phosphate + Ammonia + Hydrogen peroxide | details |
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine (PubMed:15580268). Pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP (By similarity).
- Gene Name:
- PDXP
- Uniprot ID:
- Q3ZBF9
- Molecular weight:
- 31749.0
Reactions
Pyridoxal 5'-phosphate + Water → Pyridoxal + Hydrogen phosphate | details |
Pyridoxine 5'-phosphate + Water → Pyridoxine + Hydrogen phosphate | details |
- General function:
- Involved in heparin binding
- Specific function:
- Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin (By similarity).
- Gene Name:
- LIPC
- Uniprot ID:
- Q3SZ79
- Molecular weight:
- 56826.0
Reactions
TG(16:0/16:0/16:0)[iso] + Water → DG(16:0/16:0/0:0) + Palmitic acid | details |
DG(16:0/16:0/0:0) + Water → Palmitic acid + MG(0:0/16:0/0:0) | details |
MG(0:0/16:0/0:0) + Water → Glycerol + Palmitic acid | details |
- General function:
- Energy production and conversion
- Specific function:
- Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.
- Gene Name:
- ALDH6A1
- Uniprot ID:
- Q07536
- Molecular weight:
- 58063.0
Reactions
(S)-Methylmalonic acid semialdehyde + Water + NAD + Coenzyme A → Propionyl-CoA + NADH + Hydrogen carbonate | details |
- General function:
- Lipid transport and metabolism
- Specific function:
- This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
- Gene Name:
- HMGCS2
- Uniprot ID:
- Q2KIE6
- Molecular weight:
- 56895.0
Reactions
Acetyl-CoA + Acetoacetyl-CoA + Water → 3-Hydroxy-3-methylglutaryl-CoA + Coenzyme A | details |
- General function:
- Coenzyme transport and metabolism
- Specific function:
- Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.
- Gene Name:
- MAT1A
- Uniprot ID:
- Q2KJC6
- Molecular weight:
- 43761.0
Reactions
Selenomethionine + Adenosine triphosphate + Water → Se-Adenosylselenomethionine + Hydrogen phosphate + Pyrophosphate | details |
Adenosine triphosphate + L-Methionine + Water → S-Adenosylmethionine + Hydrogen phosphate + Pyrophosphate | details |
- General function:
- Involved in 3',5'-cyclic-GMP phosphodiesterase activity
- Specific function:
- Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:8530505). Specifically regulates nitric-oxide-generated cGMP (By similarity).
- Gene Name:
- PDE5A
- Uniprot ID:
- Q28156
- Molecular weight:
- 98627.0
Reactions
Guanosine 2',3'-cyclic phosphate + Water → Guanosine monophosphate | details |
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates (By similarity). Is equally active with myo-inositol monophosphate and D-galactose 1-phosphate.
- Gene Name:
- IMPA1
- Uniprot ID:
- P20456
- Molecular weight:
- 30056.0
Reactions
Myo-inositol 1-phosphate + Water → Myoinositol + Hydrogen phosphate | details |
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- Not Available
- Gene Name:
- INPP1
- Uniprot ID:
- P21327
- Molecular weight:
- 43965.0
Reactions
1D-Myo-inositol 1,3,4,6-tetrakisphosphate + Water → 1D-Myo-inositol 3,4-bisphosphate + Pyrophosphate | details |
Inositol 1,3,4-trisphosphate + Water → 1D-Myo-inositol 3,4-bisphosphate + Hydrogen phosphate | details |
- General function:
- Inorganic ion transport and metabolism
- Specific function:
- This isozyme plays a key role in skeletal mineralization by regulating levels of diphosphate (PPi).
- Gene Name:
- ALPL
- Uniprot ID:
- P09487
- Molecular weight:
- 57193.0
Reactions
Pyridoxine 5'-phosphate + Water → Pyridoxine + Hydrogen phosphate | details |
- General function:
- Carbohydrate transport and metabolism
- Specific function:
- Glycolytic enzyme the catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (By similarity). In addition to glycolysis, involved in various processes such as growth control, hypoxia tolerance and allergic responses (PubMed:7499243). May also function in the intravascular and pericellular fibrinolytic system due to its ability to serve as a receptor and activator of plasminogen on the cell surface of several cell-types such as leukocytes and neurons (By similarity). Stimulates immunoglobulin production (By similarity).
- Gene Name:
- ENO1
- Uniprot ID:
- Q9XSJ4
- Molecular weight:
- 47326.0
Reactions
2-Phospho-D-glyceric acid → Phosphoenolpyruvic acid + Water | details |
- General function:
- Amino acid transport and metabolism
- Specific function:
- Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates (By similarity).
- Gene Name:
- PSPH
- Uniprot ID:
- Q2KHU0
- Molecular weight:
- 24850.0
Reactions
Phosphoserine + Water → L-Serine + Hydrogen phosphate | details |
- General function:
- Replication, recombination and repair
- Specific function:
- Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate) and [PP]2-InsP4 (bisdiphosphoinositol tetrakisphosphate), suggesting that it may play a role in signal transduction. InsP6 (inositol hexakisphosphate) is not a substrate. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate (By similarity).
- Gene Name:
- NUDT3
- Uniprot ID:
- A2VE79
- Molecular weight:
- 19362.0
Reactions
5-Diphosphoinositol pentakisphosphate + Water → Myo-inositol hexakisphosphate + Hydrogen phosphate | details |
- General function:
- Nucleotide transport and metabolism
- Specific function:
- Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.
- Gene Name:
- ITPA
- Uniprot ID:
- Q2KIC5
- Molecular weight:
- 23061.0
Reactions
Guanosine triphosphate + Water → Guanosine monophosphate + Pyrophosphate | details |
Inosine triphosphate + Water → Inosinic acid + Pyrophosphate | details |
Uridine triphosphate + Water → Uridine 5'-monophosphate + Pyrophosphate | details |
- General function:
- Replication, recombination and repair
- Specific function:
- Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide nucleotide cofactors required for oxidative metabolism in this organelle.
- Gene Name:
- NUDT12
- Uniprot ID:
- Q29RH3
- Molecular weight:
- 50119.0
Reactions
NAD + Water → Nicotinamide ribotide + Adenosine monophosphate | details |
Nicotinic acid adenine dinucleotide + Water → Nicotinic acid mononucleotide + Adenosine monophosphate | details |
Nicotinic acid adenine dinucleotide + Water →2 Nicotinic acid mononucleotide | details |
- General function:
- Posttranslational modification, protein turnover, chaperones
- Specific function:
- Protects the hemoglobin in erythrocytes from oxidative breakdown.
- Gene Name:
- GPX1
- Uniprot ID:
- P00435
- Molecular weight:
- 22659.0
Reactions
2 Glutathione + Hydrogen peroxide → Oxidized glutathione +2 Water | details |
15(S)-HPETE + 2 Glutathione → 15(S)-HETE + Oxidized glutathione + Water | details |
Only showing the first 50 proteins. There are 161 proteins in total.